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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-11-24
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pubmed:abstractText |
In preimplantation mammalian development the transcription factor Sox2 (SRY-related HMG-box gene 2) forms a complex with Oct4 and functions in maintenance of self-renewal of the pluripotent inner cell mass (ICM). Previously it was shown that Sox2-/- embryos die soon after implantation. However, maternal Sox2 transcripts may mask an earlier phenotype. We investigated whether Sox2 is involved in controlling cell fate decisions at an earlier stage.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Cdx2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-3,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pou5f1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SOXB1 Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Sox2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tead4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Yap protein, mouse
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e13952
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pubmed:meshHeading |
pubmed-meshheading:21103067-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:21103067-Animals,
pubmed-meshheading:21103067-Apoptosis,
pubmed-meshheading:21103067-Blastocyst,
pubmed-meshheading:21103067-Cell Differentiation,
pubmed-meshheading:21103067-Cell Lineage,
pubmed-meshheading:21103067-Cells, Cultured,
pubmed-meshheading:21103067-DNA-Binding Proteins,
pubmed-meshheading:21103067-Embryonic Stem Cells,
pubmed-meshheading:21103067-Female,
pubmed-meshheading:21103067-Gene Expression Regulation, Developmental,
pubmed-meshheading:21103067-Homeodomain Proteins,
pubmed-meshheading:21103067-Immunohistochemistry,
pubmed-meshheading:21103067-Male,
pubmed-meshheading:21103067-Mice,
pubmed-meshheading:21103067-Microscopy, Confocal,
pubmed-meshheading:21103067-Morula,
pubmed-meshheading:21103067-Muscle Proteins,
pubmed-meshheading:21103067-Octamer Transcription Factor-3,
pubmed-meshheading:21103067-Phosphoproteins,
pubmed-meshheading:21103067-RNA, Messenger,
pubmed-meshheading:21103067-RNA Interference,
pubmed-meshheading:21103067-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21103067-SOXB1 Transcription Factors,
pubmed-meshheading:21103067-Transcription Factors,
pubmed-meshheading:21103067-Trophoblasts
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pubmed:year |
2010
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pubmed:articleTitle |
Sox2 is essential for formation of trophectoderm in the preimplantation embryo.
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pubmed:affiliation |
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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