Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-12-8
pubmed:abstractText
Metabolic interactions between multiple cell types are difficult to model using existing approaches. Here we present a workflow that integrates gene expression data, proteomics data and literature-based manual curation to model human metabolism within and between different types of cells. Transport reactions are used to account for the transfer of metabolites between models of different cell types via the interstitial fluid. We apply the method to create models of brain energy metabolism that recapitulate metabolic interactions between astrocytes and various neuron types relevant to Alzheimer's disease. Analysis of the models identifies genes and pathways that may explain observed experimental phenomena, including the differential effects of the disease on cell types and regions of the brain. Constraint-based modeling can thus contribute to the study and analysis of multicellular metabolic processes in the human tissue microenvironment and provide detailed mechanistic insight into high-throughput data analysis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-11111150, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-1156396, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-11782417, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-11796747, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-12368262, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-12948754, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-14688411, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-15094077, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-15377041, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-15852400, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-16371949, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-16381900, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-16416424, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-16815214, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-16912976, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-17267599, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-17385046, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-17715058, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-17940539, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-18026122, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-18070347, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-18270320, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-18483554, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-18536691, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-18599447, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-19468334, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-19713214, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-19888215, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-20029370, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-20074521, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-20212490, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-20335275, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-20823844, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-6404910, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-7324866, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-7468149, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-8035169, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-8610107, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-9454864, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-9585920, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-9633698, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-9751184, http://linkedlifedata.com/resource/pubmed/commentcorrection/21102456-9778267
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1546-1696
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1279-85
pubmed:dateRevised
2011-9-16
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Large-scale in silico modeling of metabolic interactions between cell types in the human brain.
pubmed:affiliation
Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural