Linked Life Data

21102434

Source:http://linkedlifedata.com/resource/pubmed/id/21102434

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7325
pubmed:dateCreated
2010-12-14
pubmed:abstractText
Glioblastoma is a highly angiogenetic malignancy, the neoformed vessels of which are thought to arise by sprouting of pre-existing brain capillaries. The recent demonstration that a population of glioblastoma stem-like cells (GSCs) maintains glioblastomas indicates that the progeny of these cells may not be confined to the neural lineage. Normal neural stem cells are able to differentiate into functional endothelial cells. The connection between neural stem cells and the endothelial compartment seems to be critical in glioblastoma, where cancer stem cells closely interact with the vascular niche and promote angiogenesis through the release of vascular endothelial growth factor (VEGF) and stromal-derived factor 1 (refs 5-9). Here we show that a variable number (range 20-90%, mean 60.7%) of endothelial cells in glioblastoma carry the same genomic alteration as tumour cells, indicating that a significant portion of the vascular endothelium has a neoplastic origin. The vascular endothelium contained a subset of tumorigenic cells that produced highly vascularized anaplastic tumours with areas of vasculogenic mimicry in immunocompromised mice. In vitro culture of GSCs in endothelial conditions generated progeny with phenotypic and functional features of endothelial cells. Likewise, orthotopic or subcutaneous injection of GSCs in immunocompromised mice produced tumour xenografts, the vessels of which were primarily composed of human endothelial cells. Selective targeting of endothelial cells generated by GSCs in mouse xenografts resulted in tumour reduction and degeneration, indicating the functional relevance of the GSC-derived endothelial vessels. These findings describe a new mechanism for tumour vasculogenesis and may explain the presence of cancer-derived endothelial-like cells in several malignancies.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1476-4687
pubmed:author
pubmed:issnType
Electronic
pubmed:day
9
pubmed:volume
468
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
824-8
pubmed:dateRevised
2011-9-14
pubmed:meshHeading
pubmed-meshheading:21102434-Animals, pubmed-meshheading:21102434-Cell Differentiation, pubmed-meshheading:21102434-Cell Line, Tumor, pubmed-meshheading:21102434-Cell Lineage, pubmed-meshheading:21102434-Chromosome Aberrations, pubmed-meshheading:21102434-Endothelial Cells, pubmed-meshheading:21102434-Endothelium, Vascular, pubmed-meshheading:21102434-Glioblastoma, pubmed-meshheading:21102434-Humans, pubmed-meshheading:21102434-In Situ Hybridization, Fluorescence, pubmed-meshheading:21102434-Mice, pubmed-meshheading:21102434-Mice, Inbred NOD, pubmed-meshheading:21102434-Mice, SCID, pubmed-meshheading:21102434-Mice, Transgenic, pubmed-meshheading:21102434-Models, Biological, pubmed-meshheading:21102434-Neoplasm Transplantation, pubmed-meshheading:21102434-Neovascularization, Pathologic, pubmed-meshheading:21102434-Neural Stem Cells, pubmed-meshheading:21102434-Transplantation, Heterologous, pubmed-meshheading:21102434-Tumor Markers, Biological
pubmed:year
2010
pubmed:articleTitle
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.
pubmed:affiliation
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't