Linked Life Data

211017

Source:http://linkedlifedata.com/resource/pubmed/id/211017

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
57
pubmed:dateCreated
1978-12-2
pubmed:abstractText
Studies in simple systems have identified the reaction mechanisms likely to be involved in biological phosphate transfer and provide the background for understanding the reaction in vivo. Metabolic pathways start from inorganic phosphate, but the introduction of organophosphorus compounds allows us to by-pass early steps and modify specific enzyme-catalyzed reactions. In some cases, as with the nerve poisons, the effects are not specific to enzymes catalyzing reactions of organophosphorus compounds. But the success of any rational chemical intervention depends on both our understanding of the biochemical reaction and the current state of synthetic organophosphorus chemistry. The chemistry of the phosphate transfer process in cases where chemical intervention in metabolic processes has been successful is summarized, and some less familiar types of organophosphorus compound are discussed in the light of the apparent requirements for successful intervention.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5208
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-34
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
The organic chemistry of phosphate transfer.
pubmed:publicationType
Journal Article, Review