| pubmed-article:21098759 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21098759 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:21098759 | lifeskim:mentions | umls-concept:C0260515 | lld:lifeskim |
| pubmed-article:21098759 | lifeskim:mentions | umls-concept:C0596244 | lld:lifeskim |
| pubmed-article:21098759 | lifeskim:mentions | umls-concept:C0376571 | lld:lifeskim |
| pubmed-article:21098759 | lifeskim:mentions | umls-concept:C1511024 | lld:lifeskim |
| pubmed-article:21098759 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:21098759 | pubmed:dateCreated | 2010-12-16 | lld:pubmed |
| pubmed-article:21098759 | pubmed:abstractText | Women who carry a deleterious mutation in BRCA1 or BRCA2 have high lifetime risks of breast and ovarian cancers. However, the influence of a family history of these cancers on these risks in women with BRCA mutations is unclear. We calculated cancer incidence rates for a multinational cohort comprising 3011 women with BRCA1 or BRCA2 mutations who were followed up for a mean of 3.9 years, during which time 243 incident breast or ovarian cancers were recorded. The 10-year cumulative risks of breast cancer were 18.1% (95% confidence interval [CI] = 13.3% to 22.8%) for women with a BRCA1 mutation and 15.2% (95% CI = 9.1% to 21.2%) for women with a BRCA2 mutation. Among women with a BRCA1 mutation, the risk of breast cancer increased by 1.2-fold for each first-degree relative with breast cancer before age 50 years (hazard ratio [HR] = 1.21; 95% confidence interval [CI] = 0.94 to 1.57) and the risk of ovarian cancer increased by 1.6 fold for each first- or second-degree relative with ovarian cancer (HR = 1.61; 95% CI = 1.21 to 2.14). Among women with a BRCA2 mutation, the risk of breast cancer increased by 1.7-fold for each first-degree relative younger than 50 years with breast cancer (HR = 1.67; 95% CI = 1.04 to 2.07). | lld:pubmed |
| pubmed-article:21098759 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21098759 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21098759 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21098759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21098759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21098759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21098759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21098759 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21098759 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:21098759 | pubmed:issn | 1460-2105 | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:Hereditary... | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:NeuhausenSusa... | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:LynchHenry... | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:FoulkesWillia... | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:NarodSteven... | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:SunPingP | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:GhadirianParv... | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:LubinskiJanJ | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:RosenBarryB | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:EisenAndreaA | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:AinsworthPete... | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:Kim-SingCharm... | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:TungNadineN | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:GronwaldJacek... | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:MetcalfeKelly... | lld:pubmed |
| pubmed-article:21098759 | pubmed:author | pubmed-author:SweetKevinK | lld:pubmed |
| pubmed-article:21098759 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21098759 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21098759 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:21098759 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21098759 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21098759 | pubmed:pagination | 1874-8 | lld:pubmed |
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| pubmed-article:21098759 | pubmed:meshHeading | pubmed-meshheading:21098759... | lld:pubmed |
| pubmed-article:21098759 | pubmed:meshHeading | pubmed-meshheading:21098759... | lld:pubmed |
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| pubmed-article:21098759 | pubmed:meshHeading | pubmed-meshheading:21098759... | lld:pubmed |
| pubmed-article:21098759 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21098759 | pubmed:articleTitle | Family history of cancer and cancer risks in women with BRCA1 or BRCA2 mutations. | lld:pubmed |
| pubmed-article:21098759 | pubmed:affiliation | Women's College Research Institute, Toronto, ON, Canada. | lld:pubmed |
| pubmed-article:21098759 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21098759 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21098759 | pubmed:publicationType | Multicenter Study | lld:pubmed |
