Source:http://linkedlifedata.com/resource/pubmed/id/21098759
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
24
|
| pubmed:dateCreated |
2010-12-16
|
| pubmed:abstractText |
Women who carry a deleterious mutation in BRCA1 or BRCA2 have high lifetime risks of breast and ovarian cancers. However, the influence of a family history of these cancers on these risks in women with BRCA mutations is unclear. We calculated cancer incidence rates for a multinational cohort comprising 3011 women with BRCA1 or BRCA2 mutations who were followed up for a mean of 3.9 years, during which time 243 incident breast or ovarian cancers were recorded. The 10-year cumulative risks of breast cancer were 18.1% (95% confidence interval [CI] = 13.3% to 22.8%) for women with a BRCA1 mutation and 15.2% (95% CI = 9.1% to 21.2%) for women with a BRCA2 mutation. Among women with a BRCA1 mutation, the risk of breast cancer increased by 1.2-fold for each first-degree relative with breast cancer before age 50 years (hazard ratio [HR] = 1.21; 95% confidence interval [CI] = 0.94 to 1.57) and the risk of ovarian cancer increased by 1.6 fold for each first- or second-degree relative with ovarian cancer (HR = 1.61; 95% CI = 1.21 to 2.14). Among women with a BRCA2 mutation, the risk of breast cancer increased by 1.7-fold for each first-degree relative younger than 50 years with breast cancer (HR = 1.67; 95% CI = 1.04 to 2.07).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1460-2105
|
| pubmed:author |
pubmed-author:AinsworthPeterP,
pubmed-author:EisenAndreaA,
pubmed-author:FoulkesWilliam DWD,
pubmed-author:GhadirianParvizP,
pubmed-author:GronwaldJacekJ,
pubmed-author:Hereditary Breast Cancer Clinical Study Group,
pubmed-author:Kim-SingCharmaineC,
pubmed-author:LubinskiJanJ,
pubmed-author:LynchHenry THT,
pubmed-author:MetcalfeKellyK,
pubmed-author:NarodSteven ASA,
pubmed-author:NeuhausenSusanS,
pubmed-author:RosenBarryB,
pubmed-author:SunPingP,
pubmed-author:SweetKevinK,
pubmed-author:TungNadineN
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
102
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1874-8
|
| pubmed:meshHeading |
pubmed-meshheading:21098759-Adult,
pubmed-meshheading:21098759-Age Factors,
pubmed-meshheading:21098759-Aged,
pubmed-meshheading:21098759-BRCA1 Protein,
pubmed-meshheading:21098759-BRCA2 Protein,
pubmed-meshheading:21098759-Breast Neoplasms,
pubmed-meshheading:21098759-Cohort Studies,
pubmed-meshheading:21098759-Female,
pubmed-meshheading:21098759-Genetic Predisposition to Disease,
pubmed-meshheading:21098759-Heterozygote,
pubmed-meshheading:21098759-Humans,
pubmed-meshheading:21098759-Middle Aged,
pubmed-meshheading:21098759-Mutation,
pubmed-meshheading:21098759-Odds Ratio,
pubmed-meshheading:21098759-Ovarian Neoplasms,
pubmed-meshheading:21098759-Predictive Value of Tests,
pubmed-meshheading:21098759-Prospective Studies,
pubmed-meshheading:21098759-Risk Assessment,
pubmed-meshheading:21098759-Risk Factors
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Family history of cancer and cancer risks in women with BRCA1 or BRCA2 mutations.
|
| pubmed:affiliation |
Women's College Research Institute, Toronto, ON, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|