Source:http://linkedlifedata.com/resource/pubmed/id/21098736
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2011-1-28
|
| pubmed:abstractText |
There are three isoforms of peroxisome proliferator-activated receptor-? coactivator 1? (PGC-1?) mRNA, which promotes mitochondrial biogenesis in skeletal muscles. Compared with PGC-1?-a mRNA, PGC-1?-b or PGC-1?-c mRNA is transcribed by a different exon 1 of the PGC-1? gene. In this study, effects of exercise intensity and 5-aminoimidazole-4-carboxamide-1?-d-ribofuranoside (AICAR) on isoform-specific expressions of PGC-1? were investigated. All isoforms were increased in proportion to exercise intensity of treadmill running (10-30 m/min for 30 min). Preinjection of ??-adrenergic receptor (AR) antagonist (ICI 118551) inhibited the increase in PGC-1?-b and PGC-1?-c mRNAs, but not the increase in PGC-1?-a mRNA, in response to high-intensity exercise. Although high-intensity exercise activated ?2-AMP-activated protein kinase (?2-AMPK) in skeletal muscles, inactivation of ?2-AMPK activity did not affect high-intensity exercise-induced mRNA expression of all PGC-1? isoforms, suggesting that activation of ?2-AMPK is not mandatory for an increase in PGC-1? mRNA by high-intensity exercise. A single injection in mice of AICAR, an AMPK activator, increased mRNAs of all PGC-1? isoforms. AICAR increased blood catecholamine concentrations, and preinjection of ??-AR antagonist inhibited the increase in PGC-1?-b and PGC-1?-c mRNAs but not the increase in PGC-1?-a mRNA. Direct exposure of epitrochlearis muscle to AICAR increased PGC-1?-a but not the -b isoform. These data indicate that exercise-induced PGC-1? expression was dependent on the intensity of exercise. Exercise or AICAR injection increased PGC-1?-b and PGC-1?-c mRNAs via ??-AR activation, whereas high-intensity exercise increased PGC-1?-a expression by a multiple mechanism in which ?2-AMPK is one of the signaling pathways.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AICA ribonucleotide,
http://linkedlifedata.com/resource/pubmed/chemical/AMP-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Aminoimidazole Carboxamide,
http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/ICI 118551,
http://linkedlifedata.com/resource/pubmed/chemical/Ppargc1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Propanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1522-1555
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
300
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
E341-9
|
| pubmed:meshHeading |
pubmed-meshheading:21098736-AMP-Activated Protein Kinases,
pubmed-meshheading:21098736-Adrenergic beta-Antagonists,
pubmed-meshheading:21098736-Aminoimidazole Carboxamide,
pubmed-meshheading:21098736-Animals,
pubmed-meshheading:21098736-Catecholamines,
pubmed-meshheading:21098736-Exons,
pubmed-meshheading:21098736-Hypoglycemic Agents,
pubmed-meshheading:21098736-Isomerism,
pubmed-meshheading:21098736-Male,
pubmed-meshheading:21098736-Mice,
pubmed-meshheading:21098736-Mice, Inbred C57BL,
pubmed-meshheading:21098736-Models, Genetic,
pubmed-meshheading:21098736-Motor Activity,
pubmed-meshheading:21098736-Muscle, Skeletal,
pubmed-meshheading:21098736-Physical Conditioning, Animal,
pubmed-meshheading:21098736-Propanolamines,
pubmed-meshheading:21098736-RNA, Messenger,
pubmed-meshheading:21098736-Receptors, Adrenergic, beta-2,
pubmed-meshheading:21098736-Ribonucleotides,
pubmed-meshheading:21098736-Trans-Activators
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1? mRNA: a role of ??-adrenergic receptor activation.
|
| pubmed:affiliation |
National Institute of Health and Nutrition, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|