| pubmed-article:21098667 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21098667 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21098667 | lifeskim:mentions | umls-concept:C1335237 | lld:lifeskim |
| pubmed-article:21098667 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:21098667 | lifeskim:mentions | umls-concept:C1457869 | lld:lifeskim |
| pubmed-article:21098667 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:21098667 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:21098667 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:21098667 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:21098667 | pubmed:issue | 50 | lld:pubmed |
| pubmed-article:21098667 | pubmed:dateCreated | 2011-3-22 | lld:pubmed |
| pubmed-article:21098667 | pubmed:abstractText | The Mediator complex forms the bridge between transcriptional activators and the RNA polymerase II. Med1 (also known as PBP or TRAP220) is a key component of Mediator that interacts with nuclear hormone receptors and GATA transcription factors. Here, we show dynamic recruitment of GATA-1, TFIIB, Mediator, and RNA polymerase II to the ?-globin locus in induced mouse erythroid leukemia cells and in an erythropoietin-inducible hematopoietic progenitor cell line. Using Med1 conditional knockout mice, we demonstrate a specific block in erythroid development but not in myeloid or lymphoid development, highlighted by the complete absence of ?-globin gene expression. Thus, Mediator subunit Med1 plays a pivotal role in erythroid development and in ?-globin gene activation. | lld:pubmed |
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| pubmed-article:21098667 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21098667 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21098667 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21098667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21098667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21098667 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21098667 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:21098667 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:21098667 | pubmed:author | pubmed-author:ReddyJanardan... | lld:pubmed |
| pubmed-article:21098667 | pubmed:author | pubmed-author:SchmitzSandra... | lld:pubmed |
| pubmed-article:21098667 | pubmed:author | pubmed-author:BorggrefeTilm... | lld:pubmed |
| pubmed-article:21098667 | pubmed:author | pubmed-author:StumpfMelanie... | lld:pubmed |
| pubmed-article:21098667 | pubmed:author | pubmed-author:LucheHervéH | lld:pubmed |
| pubmed-article:21098667 | pubmed:author | pubmed-author:YueXiaojingX | lld:pubmed |
| pubmed-article:21098667 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21098667 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:21098667 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:21098667 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21098667 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21098667 | pubmed:pagination | 21541-6 | lld:pubmed |
| pubmed-article:21098667 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
| pubmed-article:21098667 | pubmed:meshHeading | pubmed-meshheading:21098667... | lld:pubmed |
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| pubmed-article:21098667 | pubmed:meshHeading | pubmed-meshheading:21098667... | lld:pubmed |
| pubmed-article:21098667 | pubmed:meshHeading | pubmed-meshheading:21098667... | lld:pubmed |
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| pubmed-article:21098667 | pubmed:meshHeading | pubmed-meshheading:21098667... | lld:pubmed |
| pubmed-article:21098667 | pubmed:meshHeading | pubmed-meshheading:21098667... | lld:pubmed |
| pubmed-article:21098667 | pubmed:meshHeading | pubmed-meshheading:21098667... | lld:pubmed |
| pubmed-article:21098667 | pubmed:meshHeading | pubmed-meshheading:21098667... | lld:pubmed |
| pubmed-article:21098667 | pubmed:meshHeading | pubmed-meshheading:21098667... | lld:pubmed |
| pubmed-article:21098667 | pubmed:meshHeading | pubmed-meshheading:21098667... | lld:pubmed |
| pubmed-article:21098667 | pubmed:meshHeading | pubmed-meshheading:21098667... | lld:pubmed |
| pubmed-article:21098667 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21098667 | pubmed:articleTitle | Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1. | lld:pubmed |
| pubmed-article:21098667 | pubmed:affiliation | Max-Planck-Institute of Immunobiology, 79108 Freiburg, Germany. | lld:pubmed |
| pubmed-article:21098667 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21098667 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21098667 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:14910 | entrezgene:pubmed | pubmed-article:21098667 | lld:entrezgene |
| entrez-gene:19014 | entrezgene:pubmed | pubmed-article:21098667 | lld:entrezgene |
