Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
50
pubmed:dateCreated
2011-3-22
pubmed:abstractText
The Mediator complex forms the bridge between transcriptional activators and the RNA polymerase II. Med1 (also known as PBP or TRAP220) is a key component of Mediator that interacts with nuclear hormone receptors and GATA transcription factors. Here, we show dynamic recruitment of GATA-1, TFIIB, Mediator, and RNA polymerase II to the ?-globin locus in induced mouse erythroid leukemia cells and in an erythropoietin-inducible hematopoietic progenitor cell line. Using Med1 conditional knockout mice, we demonstrate a specific block in erythroid development but not in myeloid or lymphoid development, highlighted by the complete absence of ?-globin gene expression. Thus, Mediator subunit Med1 plays a pivotal role in erythroid development and in ?-globin gene activation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-10747854, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-10882104, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-11430824, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-11724781, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-12379744, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-12556492, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-12672691, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-14623974, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-14759369, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15150259, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15166028, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15175162, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15684376, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15690163, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15694345, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15896740, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15896743, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15896744, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15979088, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-15989967, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-16093308, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-16286657, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-16309780, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-16634145, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-17132730, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-17171761, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-17380126, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-17438135, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-17934485, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-19171905, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-19411634, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-1987478, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-20047963, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-7660125, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-9230307, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-9325263, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-9482838, http://linkedlifedata.com/resource/pubmed/commentcorrection/21098667-9653119
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21541-6
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1.
pubmed:affiliation
Max-Planck-Institute of Immunobiology, 79108 Freiburg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural