Linked Life Data

21098404

Source:http://linkedlifedata.com/resource/pubmed/id/21098404

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2010-11-24
pubmed:abstractText
Late infantile metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder that causes severe demyelination of the nervous system. The neuronal metabolite N-acetylaspartate (NAA) serves as a source of acetyl groups for myelin lipid synthesis in oligodendrocytes and is known as a marker for neuronal and axonal loss. NAA and other metabolite levels measured by proton magnetic resonance spectroscopy (MRS) correlate with performance of the brain in normal children. There is a need for sensitive measures of disease progression in patients with MLD to enable development of future treatments.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1526-632X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
23
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1896-903
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy.
pubmed:affiliation
Department of Clinical Genetics, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. cid@dadlnet.dk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Clinical Trial, Phase I