| pubmed-article:2109837 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C0019733 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:2109837 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:2109837 | pubmed:issue | 6270 | lld:pubmed |
| pubmed-article:2109837 | pubmed:dateCreated | 1990-5-31 | lld:pubmed |
| pubmed-article:2109837 | pubmed:abstractText | Adhesion measurements between CD8 and 48 point mutants of HLA-A2.1 show that the CD8 alpha-chain binds to the alpha 3 domain of HLA-A2.1. Three clusters of alpha 3 residues contribute to the binding, with an exposed, negatively charged loop (residues 223-229) playing a dominant role. CD8 binding correlates with cytotoxic T-cell recognition and sensitivity to inhibition by anti-CD8 antibodies. Impaired alloreactive T-cell recognition of an HLA-A2.1 mutant with reduced affinity for CD8 is not restored by functional CD8 binding sites on an antigenically irrelevant class I molecule. Therefore, complexes of CD8 and the T-cell receptor bound to the same class I major histocompatibility complex molecule seem to be necessary for T-cell activation. | lld:pubmed |
| pubmed-article:2109837 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2109837 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2109837 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2109837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2109837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2109837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2109837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2109837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2109837 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2109837 | pubmed:month | May | lld:pubmed |
| pubmed-article:2109837 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2109837 | pubmed:author | pubmed-author:ClaybergerCC | lld:pubmed |
| pubmed-article:2109837 | pubmed:author | pubmed-author:ParhamPP | lld:pubmed |
| pubmed-article:2109837 | pubmed:author | pubmed-author:LittmanD RDR | lld:pubmed |
| pubmed-article:2109837 | pubmed:author | pubmed-author:KrenskyA MAM | lld:pubmed |
| pubmed-article:2109837 | pubmed:author | pubmed-author:BenjaminR JRJ | lld:pubmed |
| pubmed-article:2109837 | pubmed:author | pubmed-author:BuxtonS ESE | lld:pubmed |
| pubmed-article:2109837 | pubmed:author | pubmed-author:SalterR DRD | lld:pubmed |
| pubmed-article:2109837 | pubmed:author | pubmed-author:WesleyP KPK | lld:pubmed |
| pubmed-article:2109837 | pubmed:author | pubmed-author:GarrettT PTP | lld:pubmed |
| pubmed-article:2109837 | pubmed:author | pubmed-author:NormentA MAM | lld:pubmed |
| pubmed-article:2109837 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2109837 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:2109837 | pubmed:volume | 345 | lld:pubmed |
| pubmed-article:2109837 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2109837 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2109837 | pubmed:pagination | 41-6 | lld:pubmed |
| pubmed-article:2109837 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:meshHeading | pubmed-meshheading:2109837-... | lld:pubmed |
| pubmed-article:2109837 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2109837 | pubmed:articleTitle | A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2. | lld:pubmed |
| pubmed-article:2109837 | pubmed:affiliation | Department of Cell Biology, Stanford University, California 94305. | lld:pubmed |
| pubmed-article:2109837 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2109837 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2109837 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2109837 | lld:pubmed |
