Linked Life Data

21095834

Source:http://linkedlifedata.com/resource/pubmed/id/21095834

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-11-24
pubmed:abstractText
Retinal prostheses are being developed to restore vision for the blind with retinal diseases such as retinitis pigmentosa (RP) or age-related macular degeneration (AMD). Since neural prostheses depend upon electrical stimulation to control neural activity, optimal stimulation parameters for successful encoding of visual information are one of the most important requirements to enable visual perception. Therefore, in this paper, we focused on RGC responses to different stimulation parameters in degenerated retina. For this purpose, we used in vitro preparation of rd1 mice retina on microelectrode arrays. When the neural network of rd1 mice retinas is stimulated with voltage-controlled pulses, RGCs in degenerated retina also respond to voltage amplitude or voltage duration modulation as well in wild-type RGCs. But the temporal pattern of RGCs response is very different; in wild-type RGCs, single peak within 100 ms appears while in RGCs in degenerated retina multiple peaks (approximately 4 peaks) with approximately 10 Hz rhythm within 400 ms appear. The threshold charge densities for activation of RGCs in rd1 mouse retinas were on average 70.50 approximately 99.87 microC/cm(2) in the experiment of voltage amplitude modulation and 120.5 approxiamtely 170.6 microC/cm(2) in the experiment of voltage duration modulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1557-170X
pubmed:author
pubmed:issnType
Print
pubmed:volume
2010
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6761-4
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Retinal ganglion cell (RGC) responses to different voltage stimulation parameters in rd1 mouse retina.
pubmed:affiliation
Department of Physiology, Chungbuk National University School of Medicine, Cheongju, 361-763, Republic of Korea. tim1981@chungbuk.ac.kr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't