| pubmed-article:21093930 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21093930 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:21093930 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:21093930 | lifeskim:mentions | umls-concept:C0020852 | lld:lifeskim |
| pubmed-article:21093930 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:21093930 | lifeskim:mentions | umls-concept:C0086272 | lld:lifeskim |
| pubmed-article:21093930 | lifeskim:mentions | umls-concept:C0449445 | lld:lifeskim |
| pubmed-article:21093930 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:21093930 | pubmed:dateCreated | 2011-3-9 | lld:pubmed |
| pubmed-article:21093930 | pubmed:abstractText | 2D-immunomics may be useful in the identification of autoantigens in neurological autoimmune diseases, but its application may be limited by denaturation of target proteins. Here we compared the capacity of a single or multiple antigens to elicit autoantibodies targeting multiple neural autoantigens by ELISA and 2D-immunomics. We induced experimental autoimmune encephalomyelitis (EAE) with MBP peptide(89-104), total MBP or spinal cord homogenate. Both techniques showed anti-MBP IgG only after immunization with total MBP. In addition, 2D-immunomics revealed the presence in EAE mice of autoantibodies targeting other neural proteins, some displaying partial sequence homology with MBP. The present finding by 2D-immunomics of multiple neural proteins targeted by autoantibodies generated by a single antigen may help to explain the complex autoimmune response observed in multiple sclerosis. | lld:pubmed |
| pubmed-article:21093930 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21093930 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093930 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21093930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093930 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21093930 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21093930 | pubmed:issn | 1872-8421 | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:BonettiBrunoB | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:FarinazzoAles... | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:FurlanRoberto... | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:CecconiDaniel... | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:MarconiSilvia... | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:AnghileriElen... | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:RuffiniFrance... | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:MilliAlbertoA | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:BarbieriFranc... | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:GiniBeatriceB | lld:pubmed |
| pubmed-article:21093930 | pubmed:author | pubmed-author:TuranoErmanna... | lld:pubmed |
| pubmed-article:21093930 | pubmed:copyrightInfo | Copyright © 2010 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21093930 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21093930 | pubmed:volume | 232 | lld:pubmed |
| pubmed-article:21093930 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21093930 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21093930 | pubmed:pagination | 63-7 | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:meshHeading | pubmed-meshheading:21093930... | lld:pubmed |
| pubmed-article:21093930 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21093930 | pubmed:articleTitle | 2D immunomic approach for the study of IgG autoantibodies in the experimental model of multiple sclerosis. | lld:pubmed |
| pubmed-article:21093930 | pubmed:affiliation | Department of Neuroscience, University of Verona, Italy. | lld:pubmed |
| pubmed-article:21093930 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21093930 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
