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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-3
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pubmed:abstractText |
The present work describes a series of novel chiral amines that potently inhibit the in vitro reuptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) and were active in vivo in a mouse model predictive of antidepressant like activity. The detailed synthesis and in vitro activity and ADME profile of compounds is described, which represent a previously undisclosed triple reuptake inhibitor chemotype.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:BushLarry RLR,
pubmed-author:CampbellUna CUC,
pubmed-author:EngelSharon RSR,
pubmed-author:HardyLarry WLW,
pubmed-author:HewittMichael CMC,
pubmed-author:KochPatrickP,
pubmed-author:MaJianguoJ,
pubmed-author:MalcolmScott CSC,
pubmed-author:SaraswatLakshmi DLD,
pubmed-author:SchreiberRudyR,
pubmed-author:ShaoLimingL,
pubmed-author:SpearKerry LKL,
pubmed-author:SpicerNancy ANA,
pubmed-author:VarneyMark AMA,
pubmed-author:WangFengjiangF
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
663-76
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pubmed:meshHeading |
pubmed-meshheading:21093273-Animals,
pubmed-meshheading:21093273-Antidepressive Agents,
pubmed-meshheading:21093273-Disease Models, Animal,
pubmed-meshheading:21093273-Dopamine,
pubmed-meshheading:21093273-Drug Evaluation, Preclinical,
pubmed-meshheading:21093273-Mice,
pubmed-meshheading:21093273-Naphthalenes,
pubmed-meshheading:21093273-Neurotransmitter Uptake Inhibitors,
pubmed-meshheading:21093273-Norepinephrine,
pubmed-meshheading:21093273-Serotonin
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pubmed:year |
2011
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pubmed:articleTitle |
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
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pubmed:affiliation |
Discovery and Early Clinical Research, Sepracor Inc., 84 Waterford Drive, Marlborough, MA 01752, USA. liming.shao@sepracor.com
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pubmed:publicationType |
Journal Article
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