Source:http://linkedlifedata.com/resource/pubmed/id/21092961
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-1-11
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| pubmed:abstractText |
Bone tissue engineering is a promising strategy to repair local defects by implanting biodegradable scaffolds which undergo remodeling and are replaced completely by autologous bone tissue. Here, we consider a Keller-Segel model to describe the chemotaxis of bone marrow-derived mesenchymal stem cells (BMSCs) into a mineralized collagen scaffold. Following recent experimental results in bone healing, demonstrating that a sub-population of BMSCs can be guided into 3D scaffolds by gradients of signaling molecules such as SDF-1?, we consider a population of BMSCs on the surface of the pore structure of the scaffold and the chemoattractant SDF-1? within the pores. The resulting model is a coupled bulk/surface model which we reformulate following a diffuse-interface approach in which the geometry is implicitly described using a phase-field function. We explain how to obtain such an implicit representation and present numerical results on ?CT-data for real scaffolds, assuming a diffusion of SDF-1? being coupled to diffusion and chemotaxis of the cells towards SDF-1?. We observe a slowing-down of BMSC ingrowth after the scaffold becomes saturated with SDF-1?, suggesting that a slow release of SDF-1? avoiding an early saturation is required to enable a complete colonization of the scaffold. The validation of our results is possible via SDF-1? release from injectable carrier materials, and an adaptation of our model to similar coupled bulk/surface problems such as remodeling processes seems attractive.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1873-2380
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
11
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| pubmed:volume |
44
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
359-64
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| pubmed:meshHeading |
pubmed-meshheading:21092961-Animals,
pubmed-meshheading:21092961-Biomimetics,
pubmed-meshheading:21092961-Chemokine CXCL12,
pubmed-meshheading:21092961-Chemotactic Factors,
pubmed-meshheading:21092961-Chemotaxis,
pubmed-meshheading:21092961-Humans,
pubmed-meshheading:21092961-Imaging, Three-Dimensional,
pubmed-meshheading:21092961-Mesenchymal Stem Cells,
pubmed-meshheading:21092961-Mice,
pubmed-meshheading:21092961-Microscopy, Electron, Scanning,
pubmed-meshheading:21092961-Models, Theoretical,
pubmed-meshheading:21092961-Osteoblasts,
pubmed-meshheading:21092961-Signal Transduction,
pubmed-meshheading:21092961-Tissue Engineering
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| pubmed:year |
2011
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| pubmed:articleTitle |
Chemotaxis of mesenchymal stem cells within 3D biomimetic scaffolds--a modeling approach.
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| pubmed:affiliation |
Institute of Scientific Computing, Faculty of Mathematics and Natural Sciences, Technische Universität Dresden, Zellescher Weg 12-14, Dresden. Germany.
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| pubmed:publicationType |
Journal Article
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