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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-12-17
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pubmed:abstractText |
To identify new and useful candidate biomarkers in head and neck squamous cell carcinoma (HNSCC), we performed a genome-wide survey and found that Myelin and lymphocyte-associated protein (MAL) was a gene that was markedly down-regulated in HNSCC. Hence, we investigated the mechanism of MAL silencing and the effects of MAL on the proliferation, invasion, and apoptotic potential in HNSCC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-4598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
296
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21092172-Apoptosis,
pubmed-meshheading:21092172-Blotting, Western,
pubmed-meshheading:21092172-Carcinoma,
pubmed-meshheading:21092172-Carcinoma, Squamous Cell,
pubmed-meshheading:21092172-Cell Cycle,
pubmed-meshheading:21092172-Cell Line, Tumor,
pubmed-meshheading:21092172-Cell Proliferation,
pubmed-meshheading:21092172-DNA Methylation,
pubmed-meshheading:21092172-Epigenesis, Genetic,
pubmed-meshheading:21092172-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21092172-Head and Neck Neoplasms,
pubmed-meshheading:21092172-Humans,
pubmed-meshheading:21092172-Membrane Transport Proteins,
pubmed-meshheading:21092172-Microscopy, Confocal,
pubmed-meshheading:21092172-Myelin Proteins,
pubmed-meshheading:21092172-Neoplasms, Squamous Cell,
pubmed-meshheading:21092172-Polymerase Chain Reaction,
pubmed-meshheading:21092172-Promoter Regions, Genetic,
pubmed-meshheading:21092172-Proteolipids,
pubmed-meshheading:21092172-RNA, Messenger
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pubmed:year |
2010
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pubmed:articleTitle |
Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma.
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pubmed:affiliation |
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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