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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-12-8
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pubmed:abstractText |
Rhabdoid Tumors (RTs) are highly aggressive pediatric malignancies with poor prognosis. There are currently no standard or effective treatments for RTs in part because treatments are not designed to specifically target these tumors. Our previous studies indicated that targeting the cyclin/cdk pathway is a novel therapeutic strategy for RTs and that a pan-cdk inhibitor, flavopiridol, inhibits RT growth. Since the toxicities and narrow window of activity associated with flavopiridol may limit its clinical use, we tested the effect of combining flavopiridol with 4-hydroxy-Tamoxifen (4OH-Tam) in order to reduce the concentration of flavopiridol needed for inhibition of RTs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
634
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pubmed:meshHeading |
pubmed-meshheading:21092078-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:21092078-Apoptosis,
pubmed-meshheading:21092078-Caspases,
pubmed-meshheading:21092078-Cell Cycle,
pubmed-meshheading:21092078-Cell Survival,
pubmed-meshheading:21092078-Drug Screening Assays, Antitumor,
pubmed-meshheading:21092078-Flavonoids,
pubmed-meshheading:21092078-Flow Cytometry,
pubmed-meshheading:21092078-G2 Phase,
pubmed-meshheading:21092078-Humans,
pubmed-meshheading:21092078-Piperidines,
pubmed-meshheading:21092078-RNA Interference,
pubmed-meshheading:21092078-Rhabdoid Tumor,
pubmed-meshheading:21092078-Tamoxifen,
pubmed-meshheading:21092078-Tumor Suppressor Protein p53
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pubmed:year |
2010
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pubmed:articleTitle |
Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen.
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pubmed:affiliation |
Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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