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rdf:type |
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lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0018270,
umls-concept:C0037663,
umls-concept:C0040135,
umls-concept:C0087111,
umls-concept:C0205100,
umls-concept:C0332240,
umls-concept:C0349588,
umls-concept:C0441472,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707520,
umls-concept:C2911692
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-8
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pubmed:abstractText |
Idiopathic short stature (ISS) describes short children with normal GH secretion. Although GH treatment increases their heights, growth response to the therapy differs among patients. Thyroid hormones (TH) are essential for longitudinal growth acting mainly through TH receptors (TR) ? and ?. We have previously reported that GH treatment reduced peripheral TH action in Turner Syndrome by TR down-regulation. The aims of the study were to assess the effect of GH treatment to ISS on peripheral TH action and the correlation between thyroid status and growth response to the therapy. SUBJECTS, DESIGN AND MEASUREMENTS: Eighteen normal (control) and twenty-five ISS children were enrolled and evaluated before and after 12 months of life time (control) or 12 months of GH therapy (ISS). Fasting blood was used for serum biochemical evaluations, peripheral blood mononuclear cells for TR mRNA determination by QRT-PCR and growth parameters by standard methods.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Human Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/IGFBP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Sex Hormone-Binding Globulin,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroid Hormone Receptors beta,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroid Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1365-2265
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 Blackwell Publishing Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
346-53
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21091751-Child,
pubmed-meshheading:21091751-Growth Disorders,
pubmed-meshheading:21091751-Human Growth Hormone,
pubmed-meshheading:21091751-Humans,
pubmed-meshheading:21091751-Immunoassay,
pubmed-meshheading:21091751-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:21091751-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:21091751-Insulin-Like Growth Factor I,
pubmed-meshheading:21091751-Osteocalcin,
pubmed-meshheading:21091751-RNA, Messenger,
pubmed-meshheading:21091751-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21091751-Sex Hormone-Binding Globulin,
pubmed-meshheading:21091751-Thyroid Hormone Receptors beta,
pubmed-meshheading:21091751-Thyroid Hormones,
pubmed-meshheading:21091751-Thyrotropin,
pubmed-meshheading:21091751-Time Factors,
pubmed-meshheading:21091751-Treatment Outcome
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pubmed:year |
2011
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pubmed:articleTitle |
Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action.
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pubmed:affiliation |
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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