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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-1-28
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pubmed:abstractText |
Pancreatitis represents a life-threatening inflammatory condition where leucocytes, cytokines and vascular endothelium contribute to the development of the inflammatory disease. The glucocorticoid-induced tumour necrosis factor (TNF) receptor family-related protein (GITR) is a costimulatory molecule for T lymphocytes, modulates innate and adaptive immune system and has been found to participate in a variety of immune responses and inflammatory processes. Our purpose was to verify whether inhibition of GITR triggering results in a better outcome in experimental pancreatitis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caerulein,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoid-Induced...,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/P-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Rela protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf18 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1476-5381
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pubmed:author |
pubmed-author:BruscoliSS,
pubmed-author:CuzzocreaSS,
pubmed-author:Di PaolaRR,
pubmed-author:EspositoEE,
pubmed-author:GaluppiGG,
pubmed-author:MazzonEE,
pubmed-author:NocentiniGG,
pubmed-author:RiccardiCC,
pubmed-author:RiccardiLL,
pubmed-author:RonchettiSS,
pubmed-author:SportolettiPP
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pubmed:copyrightInfo |
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1186-201
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21091650-Animals,
pubmed-meshheading:21091650-Apoptosis,
pubmed-meshheading:21091650-Caerulein,
pubmed-meshheading:21091650-Edema,
pubmed-meshheading:21091650-Glucocorticoid-Induced TNFR-Related Protein,
pubmed-meshheading:21091650-I-kappa B Proteins,
pubmed-meshheading:21091650-Intercellular Adhesion Molecule-1,
pubmed-meshheading:21091650-Interleukin-1beta,
pubmed-meshheading:21091650-Ligands,
pubmed-meshheading:21091650-Male,
pubmed-meshheading:21091650-Mice,
pubmed-meshheading:21091650-Mice, 129 Strain,
pubmed-meshheading:21091650-Mice, Knockout,
pubmed-meshheading:21091650-Neutrophil Infiltration,
pubmed-meshheading:21091650-Nitric Oxide Synthase Type II,
pubmed-meshheading:21091650-P-Selectin,
pubmed-meshheading:21091650-Pancreatitis,
pubmed-meshheading:21091650-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:21091650-Receptors, Nerve Growth Factor,
pubmed-meshheading:21091650-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:21091650-Recombinant Fusion Proteins,
pubmed-meshheading:21091650-T-Lymphocytes,
pubmed-meshheading:21091650-Transcription Factor RelA,
pubmed-meshheading:21091650-Tumor Necrosis Factor-alpha
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pubmed:year |
2011
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pubmed:articleTitle |
The glucocorticoid-induced TNF receptor family-related protein (GITR) is critical to the development of acute pancreatitis in mice.
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pubmed:affiliation |
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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