Linked Life Data

21088796

Source:http://linkedlifedata.com/resource/pubmed/id/21088796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-9
pubmed:abstractText
Sodium balance is vital to maintaining normal physiological function. Imbalances can occur in a variety of diseases, during certain surgical operations or during rigorous exercise. There is currently no method to continuously monitor sodium concentration in patients who may be susceptible to hyponatremia. Our approach was to design sodium specific fluorescent sensors capable of measuring physiological fluctuations in sodium concentration. The sensors are submicron plasticized polymer particles containing sodium recognition components that are coated with biocompatible poly(ethylene) glycol. Here, the sensors were brought up in saline and placed in the subcutaneous area of the skin of mice by simple injection. The fluorescence was monitored in real time using a whole animal imager to track changes in sodium concentrations. This technology could be used to monitor certain disease states or warn against dangerously low levels of sodium during exercise.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1757-9708
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
142-8
pubmed:dateRevised
2011-8-22
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
In vivo sodium concentration continuously monitored with fluorescent sensors.
pubmed:affiliation
Department of Bioengineering, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
pubmed:publicationType
Journal Article