|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1978-11-18
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|
pubmed:abstractText |
Morphine and the opioid peptides leucine-enkephalin (leu-enk), methionine-enkephalin (met-enk) and beta-endorphin had no effect on basal cyclic AMP levels in rat cerebral cortex and hypothalamus, but each inhibited noradrenaline (NA)-stimulated cyclic AMP formation in both brain regions. This inhibition was reversed by naloxone. Naloxone did not reverse phentolamine- or propranolol-induced inhibition of NA-stimulated cyclic AMP formation. The increase in cyclic AMP formation induced by NaF or MnCl2 was unaffected by met-enk or morphine. These data suggest that in rat cerebral cortex and hypothalamus opiates bind to opiate receptors and that the opiate-receptor complex interferes with noradrenergic receptor activity.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0006-8993
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
8
|
|
pubmed:volume |
152
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
521-7
|
|
pubmed:dateRevised |
2003-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:210878-Animals,
pubmed-meshheading:210878-Cerebral Cortex,
pubmed-meshheading:210878-Cyclic AMP,
pubmed-meshheading:210878-Dose-Response Relationship, Drug,
pubmed-meshheading:210878-Endorphins,
pubmed-meshheading:210878-Enkephalins,
pubmed-meshheading:210878-Hypothalamus,
pubmed-meshheading:210878-Male,
pubmed-meshheading:210878-Morphine,
pubmed-meshheading:210878-Naloxone,
pubmed-meshheading:210878-Norepinephrine,
pubmed-meshheading:210878-Rats,
pubmed-meshheading:210878-Sodium
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|
pubmed:year |
1978
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|
pubmed:articleTitle |
Effect of opioid peptides on L-noradrenaline-stimulated cyclic AMP formation in homogenates of rat cerebral cortex and hypothalamus.
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|
pubmed:publicationType |
Journal Article
|
