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rdf:type |
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lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0008838,
umls-concept:C0015264,
umls-concept:C0017337,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0162493,
umls-concept:C0249197,
umls-concept:C0684249,
umls-concept:C1518174,
umls-concept:C2347610,
umls-concept:C2349975
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pubmed:dateCreated |
2010-12-2
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pubmed:abstractText |
Non-small-cell lung carcinomas (NSCLCs) exhibit poor prognosis and are usually resistant to conventional chemotherapy. Absence of p21WAF1/CIP1, a cyclin-dependent kinase (cdk) inhibitor, has been linked to drug resistance in many in vitro cellular models. RNA activation (RNAa) is a transcriptional activation phenomena guided by double-strand RNA (dsRNA) targeting promoter region of target gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
632
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pubmed:meshHeading |
pubmed-meshheading:21087528-Antineoplastic Agents,
pubmed-meshheading:21087528-Carcinoma,
pubmed-meshheading:21087528-Cell Line, Tumor,
pubmed-meshheading:21087528-Cell Proliferation,
pubmed-meshheading:21087528-Cisplatin,
pubmed-meshheading:21087528-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:21087528-Flow Cytometry,
pubmed-meshheading:21087528-Humans,
pubmed-meshheading:21087528-Lung Neoplasms,
pubmed-meshheading:21087528-Neoplasm Transplantation,
pubmed-meshheading:21087528-Promoter Regions, Genetic,
pubmed-meshheading:21087528-RNA,
pubmed-meshheading:21087528-RNA, Double-Stranded,
pubmed-meshheading:21087528-Transcription, Genetic,
pubmed-meshheading:21087528-Transcriptional Activation
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pubmed:year |
2010
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pubmed:articleTitle |
p21WAF1/CIP1 gene transcriptional activation exerts cell growth inhibition and enhances chemosensitivity to cisplatin in lung carcinoma cell.
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pubmed:affiliation |
Department of Clinical Laboratory and Research Center, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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