Linked Life Data

21086243

Source:http://linkedlifedata.com/resource/pubmed/id/21086243

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-1-28
pubmed:abstractText
The aim of the present study was to examine the association of proteins that regulate iron transport/storage content and acute phase response with oxidative stress in male and female athletes. Serum ferritin, transferrin, soluble transferrin receptor, C-reactive protein, interleukin-6 and oxidative stress parameters (reactive oxygen metabolites, superoxide anion, advanced oxidation protein products, lipid hydroperoxides, superoxide-dismutase and pro-oxidant-antioxidant balance) were determined in 138 athletes (73 females and 65 males). A general linear model indicated significant gender differences between athletes in terms of reactive oxygen metabolites (307.48 ± 61.02 VS. 276.98 ± 50.08; P=0.030), superoxide-dismutase (114.60 ± 41.64 VS. 101.42 ± 38.76; P=0.001), lipid hydroperoxides (149.84 ± 38.95 VS. 101.43 ± 39.26; P<0.001), pro-oxidant-antioxidant balance (512.40 ± 148.67 VS. 413.09 ± 120.30; P=0.002), advanced oxidation protein products (1.49 ± 0.30 VS. 0.91 ± 0.25; P<0.001) and superoxide (2.61 ± 0.36 VS. 2.22 ± 0.35; P=0.001), which were all significantly higher in females. Multivariate analysis of covariance indicated gender (P<0.001), training experience (P=0.004), C-reactive protein (P=0.002), soluble transferrin receptor (P=0.004) and transferrin (P<0.001) as significant covariates. Gender accounted for the largest proportion of variability for all oxidative stress parameters (46.3%) and female athletes were more susceptible to oxidative stress. Iron transport and storage proteins (transferrin and ferritin), but also acute phase reactants, were negatively related factors for oxidative stress. In conclusion, variation in the ferritin level may contribute to the different oxidative stress level between the sexes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1439-3964
pubmed:author
pubmed:copyrightInfo
© Georg Thieme Verlag KG Stuttgart · New York.
pubmed:issnType
Electronic
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Gender-specific oxidative stress parameters.
pubmed:affiliation
Clinical Centre of Serbia, Institute of Medical Biochemistry, Belgrade, Serbia.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't