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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-17
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pubmed:abstractText |
Translocator protein (TSPO) is a promising biomarker for neuroinflammation. We developed two new PET ligands, (18)F-PBR06 and (11)C-PBR28, to image TSPOs. Although our prior studies suggest that either of the two ligands could be used to quantify TSPOs in human brain, the studies were done in different sets of subjects. In this study, we directly compared (18)F-PBR06 and (11)C-PBR28 in eight human subjects to determine (1) whether either ligand provides more precise measurements of TSPOs and (2) whether the higher in vitro affinity of PBR06 compared to PBR28 led to higher in vivo binding of (18)F-PBR06 compared to (11)C-PBR28.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-16822554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-17156911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-17455247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-17519979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-18006619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-18024084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-18067245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-18093844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-18828015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-19119848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-19525468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-20008980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-20424634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085954-7798333
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1619-7089
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
352-7
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pubmed:dateRevised |
2011-8-29
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pubmed:meshHeading |
pubmed-meshheading:21085954-Acetanilides,
pubmed-meshheading:21085954-Adult,
pubmed-meshheading:21085954-Brain,
pubmed-meshheading:21085954-Female,
pubmed-meshheading:21085954-Humans,
pubmed-meshheading:21085954-Ligands,
pubmed-meshheading:21085954-Male,
pubmed-meshheading:21085954-Models, Biological,
pubmed-meshheading:21085954-Positron-Emission Tomography,
pubmed-meshheading:21085954-Pyrimidines,
pubmed-meshheading:21085954-Receptors, GABA
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pubmed:year |
2011
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pubmed:articleTitle |
Comparison of 18F- and 11C-labeled aryloxyanilide analogs to measure translocator protein in human brain using positron emission tomography.
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pubmed:affiliation |
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1026, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Intramural
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