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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-11-18
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pubmed:abstractText |
Lipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulation, liberating free fatty acids for energy metabolism or storage. This essential enzyme is synthesized in parenchymal cells of adipose tissue, heart, and skeletal muscle and migrates to the luminal side of the vascular endothelium where it acts upon circulating lipoproteins. Prior studies suggested that Lpl is immobilized by way of heparan sulfate proteoglycans on the endothelium, but genetically altering endothelial cell heparan sulfate had no effect on Lpl localization or lipolysis. The objective of this study was to determine if extracellular matrix proteoglycans affect Lpl distribution and triglyceride metabolism.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:BensadounAndreA,
pubmed-author:BishopJoseph RJR,
pubmed-author:EskoJeffrey DJD,
pubmed-author:FongLorenL,
pubmed-author:GonzalesJon CJC,
pubmed-author:MoultonKaren SKS,
pubmed-author:Passos-BuenoMaria RitaMR,
pubmed-author:StanfordKristin IKI,
pubmed-author:WitztumJoseph LJL,
pubmed-author:YehErikaE,
pubmed-author:YoungStephen GSG
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e13919
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pubmed:meshHeading |
pubmed-meshheading:21085708-Animals,
pubmed-meshheading:21085708-Basement Membrane,
pubmed-meshheading:21085708-Collagen Type XVIII,
pubmed-meshheading:21085708-Encephalocele,
pubmed-meshheading:21085708-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21085708-Female,
pubmed-meshheading:21085708-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:21085708-Heparan Sulfate Proteoglycans,
pubmed-meshheading:21085708-Humans,
pubmed-meshheading:21085708-Hypertriglyceridemia,
pubmed-meshheading:21085708-Immunohistochemistry,
pubmed-meshheading:21085708-Lipoprotein Lipase,
pubmed-meshheading:21085708-Lipoproteins,
pubmed-meshheading:21085708-Male,
pubmed-meshheading:21085708-Mice,
pubmed-meshheading:21085708-Mice, Inbred C57BL,
pubmed-meshheading:21085708-Mice, Knockout,
pubmed-meshheading:21085708-Microscopy, Electron, Transmission,
pubmed-meshheading:21085708-Mutation,
pubmed-meshheading:21085708-Retinal Detachment,
pubmed-meshheading:21085708-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21085708-Triglycerides
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pubmed:year |
2010
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pubmed:articleTitle |
Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans.
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pubmed:affiliation |
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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