Linked Life Data

21085186

Source:http://linkedlifedata.com/resource/pubmed/id/21085186

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-2-10
pubmed:abstractText
Neuroimmune dysregulation characterizes atopic disease, but its nature and clinical impact remain ill-defined. Induced by stress, the neurotrophin nerve growth factor (NGF) may worsen cutaneous inflammation. We therefore studied the role of NGF in the cutaneous stress response in a mouse model for atopic dermatitis-like allergic dermatitis (AlD). Combining several methods, we found that stress increased cutaneous but not serum or hypothalamic NGF in telogen mice. Microarray analysis showed increased mRNAs of inflammatory and growth factors associated with NGF in the skin. In stress-worsened AlD, NGF-neutralizing antibodies markedly reduced epidermal thickening together with NGF, neurotrophin receptor (tyrosine kinase A and p75 neurotrophin receptor), and transforming growth factor-? expression by keratinocytes but did not alter transepidermal water loss. Moreover, NGF expression by mast cells was reduced; this corresponded to reduced cutaneous tumor necrosis factor-? (TNF-?) mRNA levels but not to changes in mast cell degranulation or in the T helper type 1 (Th1)/Th2 cytokine balance. Also, eosinophils expressed TNF receptor type 2, and we observed reduced eosinophil infiltration after treatment with NGF-neutralizing antibodies. We thus conclude that NGF acts as a local stress mediator in perceived stress and allergy and that increased NGF message contributes to worsening of cutaneous inflammation mainly by enhancing epidermal hyperplasia, pro-allergic cytokine induction, and allergy-characteristic cellular infiltration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1523-1747
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
735-43
pubmed:meshHeading
pubmed-meshheading:21085186-Animals, pubmed-meshheading:21085186-Antibodies, pubmed-meshheading:21085186-Cell Movement, pubmed-meshheading:21085186-Dermatitis, Allergic Contact, pubmed-meshheading:21085186-Disease Models, Animal, pubmed-meshheading:21085186-Eosinophils, pubmed-meshheading:21085186-Female, pubmed-meshheading:21085186-Inflammation, pubmed-meshheading:21085186-Mast Cells, pubmed-meshheading:21085186-Mice, pubmed-meshheading:21085186-Mice, Inbred C57BL, pubmed-meshheading:21085186-Nerve Growth Factor, pubmed-meshheading:21085186-Protein Array Analysis, pubmed-meshheading:21085186-Receptor, Nerve Growth Factor, pubmed-meshheading:21085186-Receptors, Tumor Necrosis Factor, pubmed-meshheading:21085186-Skin, pubmed-meshheading:21085186-Stress, Physiological, pubmed-meshheading:21085186-Transforming Growth Factor beta2, pubmed-meshheading:21085186-Tumor Necrosis Factor-alpha
pubmed:year
2011
pubmed:articleTitle
Nerve growth factor partially recovers inflamed skin from stress-induced worsening in allergic inflammation.
pubmed:affiliation
Charité Center 12 (CC12) for Internal Medicine and Dermatology, Department of Psychosomatics, Psychoneuroimmunology of the Skin, Charité-University Medicine Berlin, Berlin, Germany. eva.peters@charite.de
pubmed:publicationType
Journal Article