Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-1-13
pubmed:abstractText
Alterations in white matter integrity of several cortical and subcortical circuits have been reported in relation to unipolar major depressive disorder. It is not clear whether these white matter changes precede the onset of illness. In all, 13 adolescent volunteers with no personal or family history of a psychiatric disorder (controls) and 18 adolescent volunteers with no personal history of a psychiatric illness including depression, but who were at high risk for developing unipolar depression by virtue of parental depression (high-risk youth), underwent diffusion tensor imaging studies. An automated tract-based spatial statistics method, a whole-brain voxel-by-voxel analysis, was used to analyze the scans. Population average diffusion parameter values were also calculated for each tract. Adolescents at high risk for unipolar depression had lower fractional anisotropy (FA) values in the left cingulum, splenium of the corpus callosum, superior longitudinal fasciculi, uncinate, and inferior fronto-occipital fasciculi than did controls. Altered white matter integrity in healthy adolescents at familial risk for unipolar depression suggests that it might serve as a vulnerability marker for the illness.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/DA14037, http://linkedlifedata.com/resource/pubmed/grant/DA15131, http://linkedlifedata.com/resource/pubmed/grant/DA17804, http://linkedlifedata.com/resource/pubmed/grant/DA17805, http://linkedlifedata.com/resource/pubmed/grant/MH62464, http://linkedlifedata.com/resource/pubmed/grant/MH68391, http://linkedlifedata.com/resource/pubmed/grant/R01 DA014037-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 DA014037-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DA014037-03, http://linkedlifedata.com/resource/pubmed/grant/R01 DA014037-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DA014037-05, http://linkedlifedata.com/resource/pubmed/grant/R01 DA015131-01A2, http://linkedlifedata.com/resource/pubmed/grant/R01 DA015131-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DA015131-03, http://linkedlifedata.com/resource/pubmed/grant/R01 DA015131-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DA015131-05, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017804-01, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017804-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017804-03, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017804-03S1, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017804-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017804-05, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017805-01, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017805-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017805-03, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017805-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017805-04S1, http://linkedlifedata.com/resource/pubmed/grant/R01 DA017805-05, http://linkedlifedata.com/resource/pubmed/grant/R01 MH062464-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 MH062464-02, http://linkedlifedata.com/resource/pubmed/grant/R01 MH062464-03, http://linkedlifedata.com/resource/pubmed/grant/R01 MH062464-04, http://linkedlifedata.com/resource/pubmed/grant/R01 MH062464-05, http://linkedlifedata.com/resource/pubmed/grant/R01 MH068391-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 MH068391-02, http://linkedlifedata.com/resource/pubmed/grant/R01 MH068391-03, http://linkedlifedata.com/resource/pubmed/grant/R01 MH068391-04, http://linkedlifedata.com/resource/pubmed/grant/R01 MH068391-05
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-15939837, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-20141770, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-16624579, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-16759726, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-16996092, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-17293361, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-17475743, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-18255316, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-20159343, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-20215939, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-20388528, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-20426150, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-20581685, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-2367658, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-427544, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-5440182, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-5785179, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-6639293, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-8130344, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-8192550, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-8946355, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-911222, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-9204677, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-9886780, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-9505045, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-12778119, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-7055408, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-18295509, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-18538868, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-18550597, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-18762590, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-18982175, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-19002191, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-10467296, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-10491603, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-10576297, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-10869045, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-12005176, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-12382205, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-12482069, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-12697626, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-12946880, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-13688369, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-14399272, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-15108123, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-15148381, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-19228974, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-19375071, http://linkedlifedata.com/resource/pubmed/commentcorrection/21085111-19389661
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