Linked Life Data

21084613

Source:http://linkedlifedata.com/resource/pubmed/id/21084613

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
46
pubmed:dateCreated
2010-11-18
pubmed:abstractText
Poor discrimination of nonlinguistic sounds has been implicated in language-learning problems in children, but research evidence has been inconsistent. This study included 32 participants with specific language impairment (SLI) and 32 typically developing controls aged 7-16 years. Frequency discrimination thresholds were estimated in a task where participants had to distinguish a higher-frequency tone from a 1000 Hz tone. Neurophysiological responses were assessed in an oddball paradigm. Stimuli were either 1030 or 1200 Hz pure tones (deviants) presented in a series of standard 1000 Hz tones, or syllables (deviant [da] or [bi] in a series of standard /ba/). On the behavioral task, children (7- to 11-year-olds) had high thresholds, regardless of language status, but teenagers (12-16 years) with SLI had higher thresholds than their controls. Conventional analysis of electrophysiological responses showed no difference between groups for the mismatch negativity (MMN), but the late discriminative negativity (LDN) was reduced in amplitude for smaller deviants in participants with SLI. Time-frequency analysis revealed that, whereas the MMN reflected enhanced intertrial coherence in the theta frequency band, the LDN corresponded to a period of event-related desynchronization extending across a wide low-frequency band including delta, theta, and alpha. This manifested as a drop in power in those frequencies, which was marked in the controls but reduced or absent in children with SLI across all stimulus types. This provides compelling evidence for a low-level auditory perceptual impairment in SLI that affects a processing stage after initial detection of a sound change.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-10576479, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-10656505, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-12324389, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-12625375, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-15322530, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-15535741, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-16685191, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-17115044, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-17592960, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-19439673, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-19864443, http://linkedlifedata.com/resource/pubmed/commentcorrection/21084613-8735439
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
17
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15578-84
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Lower-frequency event-related desynchronization: a signature of late mismatch responses to sounds, which is reduced or absent in children with specific language impairment.
pubmed:affiliation
Department of Experimental Psychology, University of Oxford, OX1 3UD Oxford, UK. dorothy.bishop@psy.ox.ac.uk
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't