Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1978-11-27
|
| pubmed:abstractText |
The role of cytoplasmic microfilaments in the metabolism of low-density lipoprotein by human fibroblasts was studied with the aid of cytochalasin B. At concentrations of 5--40 nmol/ml cytochalasin increased the surface binding but decreased the endocytosis of 125I-labelled low-density lipoprotein. Subsequent studies indicated that these changes reflected a reduction of the rate of internalisation of low-density lipoprotein receptors. Independent inhibitory effects were also observed on low-density lipoprotein degradation and on the cellular release of the trichloroacetic acid-soluble degradation products.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0006-3002
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
530
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
145-50
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:210829-Cytochalasin B,
pubmed-meshheading:210829-Cytoplasm,
pubmed-meshheading:210829-Dose-Response Relationship, Drug,
pubmed-meshheading:210829-Endocytosis,
pubmed-meshheading:210829-Fibroblasts,
pubmed-meshheading:210829-Humans,
pubmed-meshheading:210829-Lipoproteins, LDL,
pubmed-meshheading:210829-Protein Binding,
pubmed-meshheading:210829-Receptors, Drug
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Effects of cytochalasin B on low-density lipoproteins metabolism by cultured human fibroblasts.
|
| pubmed:publicationType |
Journal Article
|