Linked Life Data

21082994

Source:http://linkedlifedata.com/resource/pubmed/id/21082994

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-11-18
pubmed:abstractText
Polycythemia vera and essential thrombocythemia are the most common chronic myeloproliferative neoplasms; their molecular basis has been appreciated only recently and is briefly discussed in this article. Major causes of morbidity and mortality are represented by arterial and venous thrombosis, as well as by evolution to myelofibrosis or transformation to acute leukemia. Therapy is currently aimed at reducing the rate of thrombosis without increasing the risk of hematologic transformation that might be caused by exposure to cytotoxic drugs. A risk-oriented approach is employed for stratifying patients to the most appropriate therapeutic options. However, results of clinical trials with interferon, and the expected effects of novel drugs selectively targeting the abnormal pathways that are involved in the clonal myeloproliferation, are pushing therapeutic goals from disease control only to cure. These different issues, and current recommendations for treatment, will be discussed in the review.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1747-4094
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-55
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Treatment options for essential thrombocythemia and polycythemia vera.
pubmed:affiliation
UF di Ematologia, Dipartimento di Area Critica Medico-Chirurgica, Università degli Studi, Viale Morgagni, Florence, Italy. amvannucchi@unifi.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't