Linked Life Data

21082946

Source:http://linkedlifedata.com/resource/pubmed/id/21082946

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-11-18
pubmed:abstractText
microRNAs (miRNAs) are short noncoding RNAs that function as post-transcriptional negative regulators of gene expression. They have been shown to be involved in the control of cell proliferation and differentiation, as well as acting as oncogenes or tumor-suppressor genes, suggesting their involvement in cancer development and progression. Expression profiles of human miRNAs have shown that many of them are aberrantly expressed in hematological malignancies. Therefore, miRNA profiling may be useful to distinguish between normal and tumor cells, and to create signatures for a variety of leukemia subtypes. Here, we review recent evidence for the involvement of miRNAs in the pathogenesis of different hematopoietic malignancies and their potential applications in diagnosis, prognosis and therapy of human leukemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1747-4094
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
415-23
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Role of microRNAs in hematological malignancies.
pubmed:affiliation
Department of Genetics and Molecular Biology, Pasteur Cenci-Bolognetti, Sapienza University, Rome, Italy. alessandro.fatica@uniroma1.it
pubmed:publicationType
Journal Article, Review