Linked Life Data

21080911

Source:http://linkedlifedata.com/resource/pubmed/id/21080911

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-3-18
pubmed:abstractText
Here, we have first investigated the roles of ZNRD1 in angiogenesis of leukaemia. The leukaemia cell line K562 was transfected with the vector that included the full-length cDNA of ZNRD1, then the growth and angiogenesis of cells were detected. Up-regulation of ZNRD1 could significantly inhibit the growth of cells, reduce tumour microvessel densities and inhibit the VEGF (vascular endothelial growth factor) production. The results of human miRNA array and real-time PCR showed that ZNRD1 could significantly up-regulate the expression of miR-214 and down-regulate the expression of miR-296. Taken together, ZNRD1 might inhibit tumour angiogenesis and could be considered as a target for leukaemia therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1095-8355
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
321-4
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Role of ZNRD1 (zinc ribbon domain-containing 1) in angiogenesis of leukaemia cells.
pubmed:affiliation
State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China. hlhyhj@126.com
pubmed:publicationType
Journal Article