rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0032854,
umls-concept:C0033325,
umls-concept:C0174680,
umls-concept:C0185117,
umls-concept:C0338106,
umls-concept:C0681842,
umls-concept:C1335875,
umls-concept:C1561558,
umls-concept:C1705050,
umls-concept:C2911684
|
pubmed:issue |
1
|
pubmed:dateCreated |
2011-1-3
|
pubmed:abstractText |
Constitutive activation of signal transducer and activator of transcription-5 (Stat5) was recently found to be associated with tumor progression through stimulating cell proliferation and preventing apoptosis. However, it is not clear how activated Stat5 is expressed in colon cancer. We aimed to investigate the correlation between phosphorylated Stat5 (p-Stat5) expression and cell cycle regulators (cyclin D1) expression in colonic adenocarcinoma and the relationship between expression of these two proteins and various clinicopathological parameters, including overall survival.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1432-1262
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
26
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
29-35
|
pubmed:meshHeading |
pubmed-meshheading:21079973-Adenocarcinoma,
pubmed-meshheading:21079973-Adult,
pubmed-meshheading:21079973-Aged,
pubmed-meshheading:21079973-Aged, 80 and over,
pubmed-meshheading:21079973-Colonic Neoplasms,
pubmed-meshheading:21079973-Cyclin D1,
pubmed-meshheading:21079973-Female,
pubmed-meshheading:21079973-Humans,
pubmed-meshheading:21079973-Immunohistochemistry,
pubmed-meshheading:21079973-Kaplan-Meier Estimate,
pubmed-meshheading:21079973-Male,
pubmed-meshheading:21079973-Middle Aged,
pubmed-meshheading:21079973-Multivariate Analysis,
pubmed-meshheading:21079973-Phosphorylation,
pubmed-meshheading:21079973-Prognosis,
pubmed-meshheading:21079973-STAT5 Transcription Factor,
pubmed-meshheading:21079973-Tumor Suppressor Proteins
|
pubmed:year |
2011
|
pubmed:articleTitle |
Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma.
|
pubmed:affiliation |
Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, No. 150, Haping Road, Harbin, Heilongjiang Province 150040, China.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|