|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001271,
umls-concept:C0007097,
umls-concept:C0205145,
umls-concept:C0215407,
umls-concept:C0230628,
umls-concept:C0546816,
umls-concept:C0851285,
umls-concept:C1366765,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2010-11-16
|
|
pubmed:abstractText |
Tumor cell motility and invasion is governed by dynamic regulation of the cortical actin cytoskeleton. The actin-binding protein cortactin is commonly upregulated in multiple cancer types and is associated with increased cell migration. Cortactin regulates actin nucleation through the actin related protein (Arp)2/3 complex and stabilizes the cortical actin cytoskeleton. Cortactin is regulated by multiple phosphorylation events, including phosphorylation of S405 and S418 by extracellular regulated kinases (ERK)1/2. ERK1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the Arp2/3 regulator neuronal Wiskott-Aldrich syndrome protein (N-WASp), promoting actin polymerization and enhancing tumor cell movement.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/CTTN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cortactin,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MAPK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Wiskott-Aldrich Syndrome Protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1932-6203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e13847
|
|
pubmed:meshHeading |
pubmed-meshheading:21079800-Actins,
pubmed-meshheading:21079800-Blotting, Western,
pubmed-meshheading:21079800-Cell Line, Tumor,
pubmed-meshheading:21079800-Cell Movement,
pubmed-meshheading:21079800-Cortactin,
pubmed-meshheading:21079800-Epidermal Growth Factor,
pubmed-meshheading:21079800-Green Fluorescent Proteins,
pubmed-meshheading:21079800-Humans,
pubmed-meshheading:21079800-Microscopy, Confocal,
pubmed-meshheading:21079800-Microscopy, Fluorescence,
pubmed-meshheading:21079800-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:21079800-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:21079800-Molecular Dynamics Simulation,
pubmed-meshheading:21079800-Neoplasms,
pubmed-meshheading:21079800-Phosphorylation,
pubmed-meshheading:21079800-Protein Conformation,
pubmed-meshheading:21079800-Pseudopodia,
pubmed-meshheading:21079800-RNA Interference,
pubmed-meshheading:21079800-Serine,
pubmed-meshheading:21079800-Tyrosine,
pubmed-meshheading:21079800-Wiskott-Aldrich Syndrome Protein
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.
|
|
pubmed:affiliation |
Department of Neurobiology and Anatomy, Program in Cancer Cell Biology, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
