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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-11-16
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pubmed:abstractText |
We have previously shown that serum/glucocorticoid regulated kinase 1 (SGK1) is down-regulated in colorectal cancers (CRC) with respect to normal tissue. As hyper-methylation of promoter regions is a well-known mechanism of gene silencing in cancer, we tested whether the SGK1 promoter region was methylated in colonic tumour samples.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e13840
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:21079778-Azacitidine,
pubmed-meshheading:21079778-Blotting, Western,
pubmed-meshheading:21079778-Cell Line, Tumor,
pubmed-meshheading:21079778-Colorectal Neoplasms,
pubmed-meshheading:21079778-CpG Islands,
pubmed-meshheading:21079778-DNA Methylation,
pubmed-meshheading:21079778-Down-Regulation,
pubmed-meshheading:21079778-Enzyme Inhibitors,
pubmed-meshheading:21079778-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21079778-HCT116 Cells,
pubmed-meshheading:21079778-HT29 Cells,
pubmed-meshheading:21079778-Humans,
pubmed-meshheading:21079778-Immediate-Early Proteins,
pubmed-meshheading:21079778-Polymorphism, Single Nucleotide,
pubmed-meshheading:21079778-Promoter Regions, Genetic,
pubmed-meshheading:21079778-Protein-Serine-Threonine Kinases,
pubmed-meshheading:21079778-Receptors, Glucocorticoid,
pubmed-meshheading:21079778-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2010
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pubmed:articleTitle |
Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.
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pubmed:affiliation |
Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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