Linked Life Data

21077767

Source:http://linkedlifedata.com/resource/pubmed/id/21077767

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-11-16
pubmed:abstractText
Hb Constant Spring [Hb CS, ?142(H19)Term] and Hb Paksé [?142(H19)Term] occur from the mutation in the termination codon of the ?2-globin gene, TAA>CAA (?Gln) and TAA>TAT (?Tyr), respectively. They are the most common nondeletional ?-thalassemia (?-thal) variants causing Hb H disease in Southeast Asia. In this study, 587 cord blood samples were screened for the Hb CS and Hb Paksé mutations by a dot-blot hybridization technique using oligonucleotide probes specific for each mutation. The results showed that the prevalence of Hb CS and Hb Paksé in Central Thailand are 5.80 and 0.51%, respectively, which is in concordance with the results from previous studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1532-432X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
582-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Molecular screening of the Hbs Constant Spring (codon 142, TAA>CAA, ?2) and Paksé (codon 142, TAA>TAT, ?2) mutations in Thailand.
pubmed:affiliation
Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakornpathom, Thailand.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't