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rdf:type |
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lifeskim:mentions |
umls-concept:C0037813,
umls-concept:C0205216,
umls-concept:C0221102,
umls-concept:C0229671,
umls-concept:C0302908,
umls-concept:C0360714,
umls-concept:C0441889,
umls-concept:C0442087,
umls-concept:C0597198,
umls-concept:C0728475,
umls-concept:C1524063
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pubmed:dateCreated |
2010-11-15
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pubmed:abstractText |
Using our statin analysis method, it was possible to uncover a significant drop in statin levels (atorvastatin, simvastatin, and metabolites) after extracorporeal LDL-cholesterol elimination (EE) in severe familial hypercholesterolemia (FH). The purpose of this work was to identify the mechanism underlying this drop and its clinical significance as well as to propose measures to optimize a pharmacotherapeutical regimen that can prevent the loss of statins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1110-7251
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2011
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
912472
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pubmed:meshHeading |
pubmed-meshheading:21076535-Adult,
pubmed-meshheading:21076535-Anticholesteremic Agents,
pubmed-meshheading:21076535-Blood Component Removal,
pubmed-meshheading:21076535-Cholesterol, LDL,
pubmed-meshheading:21076535-Chromatography, High Pressure Liquid,
pubmed-meshheading:21076535-Female,
pubmed-meshheading:21076535-Hemofiltration,
pubmed-meshheading:21076535-Heptanoic Acids,
pubmed-meshheading:21076535-Humans,
pubmed-meshheading:21076535-Hyperlipoproteinemia Type II,
pubmed-meshheading:21076535-Male,
pubmed-meshheading:21076535-Middle Aged,
pubmed-meshheading:21076535-Pyrroles,
pubmed-meshheading:21076535-Simvastatin,
pubmed-meshheading:21076535-Statistics, Nonparametric,
pubmed-meshheading:21076535-Tandem Mass Spectrometry
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pubmed:year |
2011
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pubmed:articleTitle |
Use of ultra high performance liquid chromatography-tandem mass spectrometry to demonstrate decreased serum statin levels after extracorporeal LDL-cholesterol elimination.
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pubmed:affiliation |
2nd Department of Internal Medicine, Hematology, Medical Faculty and Teaching Hospital, Charles University, Hradec Králové, Czech Republic. blaham@email.cz
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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