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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-7
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pubmed:abstractText |
Iron replacement therapy is a common treatment in patients with anaemia and Crohn's disease, but oral iron supplements are less tolerated. The pathogenesis of Crohn's disease is attributed to intestinal bacteria and environmental factors that trigger disease in a genetically predisposed host. The aim of this study was to characterise the interrelationship between luminal iron sulfate, systemic iron, the gut microbiota and the development of chronic ileitis in a murine model of Crohn's disease.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1468-3288
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-33
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pubmed:meshHeading |
pubmed-meshheading:21076126-Animals,
pubmed-meshheading:21076126-Apoptosis,
pubmed-meshheading:21076126-Cecum,
pubmed-meshheading:21076126-Cell Line,
pubmed-meshheading:21076126-Chronic Disease,
pubmed-meshheading:21076126-Coculture Techniques,
pubmed-meshheading:21076126-Crohn Disease,
pubmed-meshheading:21076126-Disease Models, Animal,
pubmed-meshheading:21076126-Endoplasmic Reticulum,
pubmed-meshheading:21076126-Ileitis,
pubmed-meshheading:21076126-Ileum,
pubmed-meshheading:21076126-Intestinal Mucosa,
pubmed-meshheading:21076126-Iron,
pubmed-meshheading:21076126-Iron, Dietary,
pubmed-meshheading:21076126-Mice,
pubmed-meshheading:21076126-Mice, Inbred C57BL,
pubmed-meshheading:21076126-Stress, Physiological,
pubmed-meshheading:21076126-T-Lymphocytes, Cytotoxic
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pubmed:year |
2011
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pubmed:articleTitle |
Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis.
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pubmed:affiliation |
Biofunctionality, Technische Universität München, Freising-Weihenstephan, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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