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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-6
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pubmed:abstractText |
Designed ankyrin repeat proteins (DARPins) hold great promise as a new class of binding molecules to overcome the limitations of antibodies for biomedical applications. Here, we assessed the potential of an epithelial cell adhesion molecule (EpCAM)-specific DARPin (Ec4) for tumor targeting as a fusion toxin with Pseudomonas aeruginosa exotoxin A.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:copyrightInfo |
©2010 AACR.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
100-10
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pubmed:meshHeading |
pubmed-meshheading:21075824-ADP Ribose Transferases,
pubmed-meshheading:21075824-Animals,
pubmed-meshheading:21075824-Ankyrin Repeat,
pubmed-meshheading:21075824-Antineoplastic Agents,
pubmed-meshheading:21075824-Bacterial Toxins,
pubmed-meshheading:21075824-Cell Adhesion Molecules,
pubmed-meshheading:21075824-Cell Line, Tumor,
pubmed-meshheading:21075824-Cell Survival,
pubmed-meshheading:21075824-Exotoxins,
pubmed-meshheading:21075824-Female,
pubmed-meshheading:21075824-Humans,
pubmed-meshheading:21075824-Injections, Intravenous,
pubmed-meshheading:21075824-Mice,
pubmed-meshheading:21075824-Mice, Nude,
pubmed-meshheading:21075824-Neoplasms, Experimental,
pubmed-meshheading:21075824-Protein Engineering,
pubmed-meshheading:21075824-Pseudomonas aeruginosa,
pubmed-meshheading:21075824-Recombinant Fusion Proteins,
pubmed-meshheading:21075824-Virulence Factors,
pubmed-meshheading:21075824-Xenograft Model Antitumor Assays
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pubmed:year |
2011
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pubmed:articleTitle |
A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity.
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pubmed:affiliation |
Department of Biochemistry, University of Zürich, Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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