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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-4-25
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pubmed:abstractText |
This paper describes the successful design and development of dual pharmacology ?-2 agonists-M3 antagonists, for the treatment of chronic obstructive pulmonary disorder using the principles of 'inhalation by design'. A key feature of this work is the combination of balanced potency and pharmacodynamic duration with desirable pharmacokinetic and material properties, whilst keeping synthetic complexity to a minimum.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BaldockHelenH,
pubmed-author:BunnageMark EME,
pubmed-author:BurrowsJaneJ,
pubmed-author:ClarkeNickN,
pubmed-author:CoghlanMicheleM,
pubmed-author:EntwistleDavidD,
pubmed-author:FairmanDavidD,
pubmed-author:FeederNeilN,
pubmed-author:FluxWW,
pubmed-author:FultonCraigC,
pubmed-author:HiltonLauraL,
pubmed-author:JamraM AMA,
pubmed-author:JonesRhys MRM,
pubmed-author:KenyonAmy SAS,
pubmed-author:MarshallStuartS,
pubmed-author:NewmanSandra DSD,
pubmed-author:OsborneRachelR,
pubmed-author:PatelSheenaS,
pubmed-author:PriceDavid ADA,
pubmed-author:SelbyMatthew DMD,
pubmed-author:StuartEmilio FEF,
pubmed-author:TrevethickMichael AMA,
pubmed-author:WrightKaren NKN
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2759-63
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pubmed:meshHeading |
pubmed-meshheading:21075627-Administration, Inhalation,
pubmed-meshheading:21075627-Adrenergic beta-2 Receptor Agonists,
pubmed-meshheading:21075627-Animals,
pubmed-meshheading:21075627-Benzhydryl Compounds,
pubmed-meshheading:21075627-Cresols,
pubmed-meshheading:21075627-Drug Design,
pubmed-meshheading:21075627-Drug Therapy, Combination,
pubmed-meshheading:21075627-Guinea Pigs,
pubmed-meshheading:21075627-Molecular Structure,
pubmed-meshheading:21075627-Muscarinic Antagonists,
pubmed-meshheading:21075627-Phenylpropanolamine,
pubmed-meshheading:21075627-Pulmonary Disease, Chronic Obstructive
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pubmed:year |
2011
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pubmed:articleTitle |
Inhalation by design: dual pharmacology ?-2 agonists/M3 antagonists for the treatment of COPD.
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pubmed:affiliation |
Sandwich Chemistry, World Wide Medicinal Chemistry, Pfizer, Ramsgate Road, Sandwich CT13 9NJ, UK. lyn.jones@pfizer.com
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pubmed:publicationType |
Journal Article
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