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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1990-4-26
|
| pubmed:abstractText |
Maternal lupus anticoagulants and anticardiolipin antibodies are associated with a syndrome of recurrent pregnancy loss or preterm birth in live-borns, fetal growth retardation, and placental infarction. Fourteen women with one or more abnormal pregnancy outcomes (total 28 losses, one severely growth-retarded premature live-born) and no normal outcomes were treated with full-dose, subcutaneous, twice-daily heparin therapy in subsequent pregnancies. Treatment was started at an estimated gestational age of 10.3 +/- 4.0 (mean +/- SD) weeks (range 6-18), in a mean total daily dosage of 24,700 +/- 7400 units (range 10,000-36,000). Fourteen of 15 pregnancies resulted in live births at 36.1 +/- 1.7 weeks (range 33-39). The mean birth weight percentile was 57 +/- 21 (range 10-90), and Apgar scores were good to excellent. The number of placental infarcts was fewer in treated cases than in previous deliveries. Five fetuses had third-trimester or perinatal problems with no sequelae, four discovered by close maternal-fetal monitoring. There was an increased rate of preterm and cesarean deliveries. Maternal complications of treatment were few and minor, with no hypertension, preeclampsia, or serious drug-related complications. Heparin appears suitable for further investigation in the treatment of this obstetric syndrome.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Coagulation Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Cardiolipins,
http://linkedlifedata.com/resource/pubmed/chemical/Heparin,
http://linkedlifedata.com/resource/pubmed/chemical/Lupus Coagulation Inhibitor
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0029-7844
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
75
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
630-4
|
| pubmed:dateRevised |
2009-10-26
|
| pubmed:meshHeading |
pubmed-meshheading:2107479-Abortion, Spontaneous,
pubmed-meshheading:2107479-Adult,
pubmed-meshheading:2107479-Autoantibodies,
pubmed-meshheading:2107479-Birth Weight,
pubmed-meshheading:2107479-Blood Coagulation Factors,
pubmed-meshheading:2107479-Cardiolipins,
pubmed-meshheading:2107479-Female,
pubmed-meshheading:2107479-Fetal Diseases,
pubmed-meshheading:2107479-Heparin,
pubmed-meshheading:2107479-Humans,
pubmed-meshheading:2107479-Infant, Newborn,
pubmed-meshheading:2107479-Infarction,
pubmed-meshheading:2107479-Lupus Coagulation Inhibitor,
pubmed-meshheading:2107479-Lupus Erythematosus, Systemic,
pubmed-meshheading:2107479-Obstetric Labor, Premature,
pubmed-meshheading:2107479-Placenta,
pubmed-meshheading:2107479-Pregnancy,
pubmed-meshheading:2107479-Pregnancy Complications,
pubmed-meshheading:2107479-Pregnancy Complications, Cardiovascular,
pubmed-meshheading:2107479-Recurrence,
pubmed-meshheading:2107479-Retrospective Studies,
pubmed-meshheading:2107479-Thrombosis
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Heparin therapy for pregnant women with lupus anticoagulant or anticardiolipin antibodies.
|
| pubmed:affiliation |
Department of Medicine, University of California, Los Angeles School of Medicine.
|
| pubmed:publicationType |
Journal Article
|