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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-11-12
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pubmed:databankReference |
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pubmed:abstractText |
Flavopiridol is a cyclin-dependent kinase inhibitor in phase II clinical development for treatment of various forms of cancer. When administered with a pharmacokinetically (PK)-directed dosing schedule, flavopiridol exhibited striking activity in patients with refractory chronic lymphocytic leukemia. This study aimed to evaluate pharmacogenetic factors associated with inter-individual variability in pharmacokinetics and outcomes associated with flavopiridol therapy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCG2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Multidrug Resistance-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Anion Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/SLCO1B1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/UDP-glucuronosyltransferase 1A9,
http://linkedlifedata.com/resource/pubmed/chemical/bilirubin...,
http://linkedlifedata.com/resource/pubmed/chemical/flavopiridol,
http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance-associated...
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:AhnSunjooS,
pubmed-author:ByrdJohn CJC,
pubmed-author:DaiZunyanZ,
pubmed-author:DaltonJames TJT,
pubmed-author:FarleyKatherine LKL,
pubmed-author:GreverMichael RMR,
pubmed-author:JarjouraDavidD,
pubmed-author:JohnsonAmy JAJ,
pubmed-author:LiXiaobaiX,
pubmed-author:LinThomas STS,
pubmed-author:LuyMM,
pubmed-author:NiWenjunW,
pubmed-author:PappAudreyA,
pubmed-author:PhelpsMitch AMA,
pubmed-author:SadeeWolfgangW
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e13792
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pubmed:meshHeading |
pubmed-meshheading:21072184-ATP-Binding Cassette Transporters,
pubmed-meshheading:21072184-Adult,
pubmed-meshheading:21072184-Aged,
pubmed-meshheading:21072184-Aged, 80 and over,
pubmed-meshheading:21072184-Analysis of Variance,
pubmed-meshheading:21072184-Animals,
pubmed-meshheading:21072184-Cell Line,
pubmed-meshheading:21072184-Female,
pubmed-meshheading:21072184-Flavonoids,
pubmed-meshheading:21072184-Genotype,
pubmed-meshheading:21072184-Glucuronosyltransferase,
pubmed-meshheading:21072184-HEK293 Cells,
pubmed-meshheading:21072184-Humans,
pubmed-meshheading:21072184-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:21072184-Male,
pubmed-meshheading:21072184-Metabolic Clearance Rate,
pubmed-meshheading:21072184-Middle Aged,
pubmed-meshheading:21072184-Models, Biological,
pubmed-meshheading:21072184-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:21072184-Neoplasm Proteins,
pubmed-meshheading:21072184-Organic Anion Transporters,
pubmed-meshheading:21072184-Piperidines,
pubmed-meshheading:21072184-Polymorphism, Single Nucleotide,
pubmed-meshheading:21072184-Protein Kinase Inhibitors,
pubmed-meshheading:21072184-Tissue Distribution
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pubmed:year |
2010
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pubmed:articleTitle |
Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.
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pubmed:affiliation |
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America.
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pubmed:publicationType |
Journal Article,
Clinical Trial, Phase II,
Research Support, N.I.H., Extramural
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