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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0012155,
umls-concept:C0016390,
umls-concept:C0021368,
umls-concept:C0034821,
umls-concept:C0205195,
umls-concept:C0206745,
umls-concept:C0221198,
umls-concept:C0262950,
umls-concept:C1412058,
umls-concept:C1413218,
umls-concept:C1442161,
umls-concept:C1522492,
umls-concept:C1527148,
umls-concept:C2349975
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-14
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pubmed:abstractText |
macrophages cannot limit the uptake of lipids and rely on cholesterol efflux mechanisms for maintaining cellular cholesterol homeostasis. Important mediators of macrophage cholesterol efflux are ATP-binding cassette transporter 1 (ABCA1), which mediates the efflux of cholesterol to lipid-poor apolipoprotein AI, and scavenger receptor class B type I (SR-BI), which promotes efflux to mature high-density lipoprotein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4571
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pubmed:author |
pubmed-author:Calpe-BerdielLauraL,
pubmed-author:ChiminiGiovannaG,
pubmed-author:GroenAlbert KAK,
pubmed-author:HildebrandReeni BRB,
pubmed-author:HoekstraMennoM,
pubmed-author:Hurt-CamejoEvaE,
pubmed-author:JessupWendyW,
pubmed-author:KjerrulfMartinM,
pubmed-author:OutRuudR,
pubmed-author:PenningsMariekeM,
pubmed-author:ROEW FWF,
pubmed-author:Van BerkelTheo J CTJ,
pubmed-author:Van EckMirandaM,
pubmed-author:YeDanD
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e20-31
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pubmed:meshHeading |
pubmed-meshheading:21071707-ATP-Binding Cassette Transporters,
pubmed-meshheading:21071707-Animals,
pubmed-meshheading:21071707-Atherosclerosis,
pubmed-meshheading:21071707-Bone Marrow,
pubmed-meshheading:21071707-Bone Marrow Transplantation,
pubmed-meshheading:21071707-Cholesterol,
pubmed-meshheading:21071707-Foam Cells,
pubmed-meshheading:21071707-Gene Deletion,
pubmed-meshheading:21071707-Homeostasis,
pubmed-meshheading:21071707-Inflammation,
pubmed-meshheading:21071707-Lipid Metabolism,
pubmed-meshheading:21071707-Lipoproteins, LDL,
pubmed-meshheading:21071707-Macrophages,
pubmed-meshheading:21071707-Mice,
pubmed-meshheading:21071707-Mice, Knockout,
pubmed-meshheading:21071707-Scavenger Receptors, Class B
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pubmed:year |
2010
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pubmed:articleTitle |
Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet.
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pubmed:affiliation |
Division of Biopharmaceutics, University Medical Center Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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