Incubation of chronic myeloid leukemia cells in hypoxia inhibits growth and selects BCR/Abl-independent cells with stem cell properties which are refractory to imatinib-mesylate. This study aimed to characterize the relationship of this refractoriness with glucose availability in the environment.
Dipartimento di Patologia e Oncologia Sperimentali, Università degli Studi di Firenze and Istituto Toscano Tumori, Viale G.B. Morgagni 50, I-50134, Firenze, Italia.