Linked Life Data

21070476

Source:http://linkedlifedata.com/resource/pubmed/id/21070476

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-12-16
pubmed:abstractText
?-Catenin is the only member of the p120 catenin (p120ctn) subfamily that its primary expression is restricted to the brain. Since ?-catenin is upregulated in human lung cancer, the effects of ?-catenin overexpression in lung cancer still need to be clarified. Immunohistochemistry was performed to investigate the expression of ?-catenin and Kaiso, a ?-catenin-binding transcription factor, in 151 lung cancer specimens. A correlation between cytoplasmic ?-catenin and Kaiso expression was also associated with high TNM stage, lymph node metastases and poor prognosis. Co-immunoprecipitation assay confirmed the interactions of ?-catenin and Kaiso in lung cancer cells. In addition, gene transfection and RNAi technology were used to demonstrate that increased ?-catenin expression was promoted, whereas its knockdown suppressed its lung cancer invasive ability. In addition, methylation-specific PCR and ChIP assay demonstrated that ?-catenin could regulate MTA2 via Kaiso in a methylation-dependent manner, while it could regulate cyclin D1 and MMP7 expression through Kaiso in a sequence-specific manner. In conclusion, a ?-catenin/Kaiso pathway exists in lung cancer cells. Increased ?-catenin expression is critical for maintenance of the malignant phenotype of lung cancer, making ?-catenin a candidate target protein for future cancer therapeutics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1349-7006
pubmed:author
pubmed:copyrightInfo
© 2010 Japanese Cancer Association.
pubmed:issnType
Electronic
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-103
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Upregulation of ?-catenin is associated with poor prognosis and enhances transcriptional activity through Kaiso in non-small-cell lung cancer.
pubmed:affiliation
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't