Source:http://linkedlifedata.com/resource/pubmed/id/21069577
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-3-22
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| pubmed:abstractText |
To investigate the contribution of glycosylated haemoglobin change (HbA1c) on body weight in patients with type 2 diabetes after start of insulin therapy. We analysed 122 individual weight-profiles in relation to the change in HbA1c per se in these patients up to 36 months after the start of insulin therapy. Data were analysed separately for the first 9 months after commencement of insulin therapy and for the period thereafter. Within the first 9 months of insulin therapy mean body weight increased by 0.52 kg per month. HbA1c decreased from 9.9 ± 1.8 to 7.9 ± 1.3%. Only 12% of the initial weight gain could be attributed to the change in HbA1c. Furthermore, the mean monthly increase in body weight gain was reduced by 0.006 kg for every 1 kg higher body weight at baseline. From 9 to 36 months after start of insulin therapy, body weight increased by 0.1 kg/month, which was independent of change in HbA1c. Improvement of glycaemic control per se contributes little to initial weight gain after start of insulin therapy in patients with T2DM. After 9 months of insulin treatment, weight gain is unrelated to change in glycosylated haemoglobin. Other factors have to be responsible for weight gain after start of insulin therapy.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
1559-0100
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
39
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
190-7
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:21069577-Adult,
pubmed-meshheading:21069577-Aged,
pubmed-meshheading:21069577-Aged, 80 and over,
pubmed-meshheading:21069577-Body Weight,
pubmed-meshheading:21069577-Diabetes Mellitus, Type 2,
pubmed-meshheading:21069577-Female,
pubmed-meshheading:21069577-Hemoglobin A, Glycosylated,
pubmed-meshheading:21069577-Humans,
pubmed-meshheading:21069577-Hyperglycemia,
pubmed-meshheading:21069577-Hypoglycemic Agents,
pubmed-meshheading:21069577-Insulin,
pubmed-meshheading:21069577-Longitudinal Studies,
pubmed-meshheading:21069577-Male,
pubmed-meshheading:21069577-Medical Records,
pubmed-meshheading:21069577-Middle Aged,
pubmed-meshheading:21069577-Netherlands,
pubmed-meshheading:21069577-Obesity,
pubmed-meshheading:21069577-Retrospective Studies,
pubmed-meshheading:21069577-Risk Factors,
pubmed-meshheading:21069577-Statistics as Topic,
pubmed-meshheading:21069577-Time Factors,
pubmed-meshheading:21069577-Weight Gain
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Contribution of change in glycosylated haemoglobin to insulin-associated weight gain: results of a longitudinal study in type 2 diabetic patients.
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| pubmed:affiliation |
Department of General Internal Medicine 463, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. H.Jansen@AIG.umcn.nl
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| pubmed:publicationType |
Journal Article
|