Source:http://linkedlifedata.com/resource/pubmed/id/21069307
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-1-3
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| pubmed:abstractText |
Transcranial magnetic stimulation (TMS) interventions that modulate cortical plasticity may achieve a more functional benefit if combined with neuro-rehabilitation therapies. With a TMS protocol targeting I-wave dynamics, it is possible to deliver stimuli while a subject performs a motor task, and this may more effectively target functional networks related to the task. However, the efficacy of this intervention during a simple task such as a low-level voluntary contraction is not known. We delivered paired-pulse TMS at an inter-pulse interval (IPI) of 1.5 ms for 15 min while subjects performed a 10 ± 2.5% voluntary contraction of the first dorsal interosseous (FDI) muscle and made motor evoked potential (MEP) amplitude and short-interval intracortical facilitation (SICF) curve measurements. Pre-intervention SICF curves showed only a single peak at 1.3-1.5 ms IPI. During the intervention, MEP amplitude steadily increased (P < 0.001) to 137 ± 13% of its initial value. After the intervention, SICF curves were increased in amplitude (P < 0.001) and later peaks emerged at 2.8 and 4.3 ms IPIs. A control experiment, replacing paired-pulse stimulation with single-pulse stimulation showed no effect on MEP amplitude (P = 0.951). We conclude that the I-wave intervention can be administered concurrently with a simple motor task and that it acts by increasing trans-synaptic efficacy across a number of I-waves. The ability to perform a motor task simultaneously with a TMS intervention could confer a degree of specificity to the induced excitability changes and may be beneficial for functional neuro-rehabilitation programs built around motor learning and retraining.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1432-1106
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
208
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
229-35
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| pubmed:meshHeading |
pubmed-meshheading:21069307-Adolescent,
pubmed-meshheading:21069307-Adult,
pubmed-meshheading:21069307-Electric Stimulation,
pubmed-meshheading:21069307-Evoked Potentials, Motor,
pubmed-meshheading:21069307-Female,
pubmed-meshheading:21069307-Humans,
pubmed-meshheading:21069307-Male,
pubmed-meshheading:21069307-Muscle, Skeletal,
pubmed-meshheading:21069307-Muscle Contraction,
pubmed-meshheading:21069307-Reaction Time,
pubmed-meshheading:21069307-Time Factors,
pubmed-meshheading:21069307-Transcranial Magnetic Stimulation,
pubmed-meshheading:21069307-Young Adult
|
| pubmed:year |
2011
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| pubmed:articleTitle |
Modulation of corticomotor excitability by an I-wave intervention delivered during low-level voluntary contraction.
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| pubmed:affiliation |
Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, Nedlands, WA 6009, Australia.
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| pubmed:publicationType |
Journal Article
|