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rdf:type |
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lifeskim:mentions |
umls-concept:C0009402,
umls-concept:C0027540,
umls-concept:C0086418,
umls-concept:C0205195,
umls-concept:C1515877,
umls-concept:C1516044,
umls-concept:C1518174,
umls-concept:C1522449,
umls-concept:C1704259,
umls-concept:C1704628,
umls-concept:C1705987,
umls-concept:C1879547,
umls-concept:C2728259
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pubmed:issue |
11
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pubmed:dateCreated |
2010-11-12
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pubmed:abstractText |
The malignancy of tumor cells can be attenuated by interfering with cell death pathways. Since hyperthermia (HT) is a very potent radiosensitizer, the influence of HT (41.5 °C for 1 hour) alone and in combination with ionising irradiation (X-ray; 5 Gy or 10 Gy) on the form of cell death as well as on the expression of proteins known to be major components in tumor cells' apoptotic and necrotic pathways were examined in colorectal tumor cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BBC3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 7,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-6,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1439-099X
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pubmed:author |
pubmed-author:FietkauRainerR,
pubmed-author:FreyBenjaminB,
pubmed-author:GaiplUdo SUS,
pubmed-author:HaslingerStefanS,
pubmed-author:LödermannBarbaraB,
pubmed-author:MantelFrederickF,
pubmed-author:OttOliver JOJ,
pubmed-author:RödelFranzF,
pubmed-author:SauerRolfR,
pubmed-author:SchildkopfPetraP,
pubmed-author:SieberRenateR
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pubmed:issnType |
Electronic
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
587-99
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pubmed:meshHeading |
pubmed-meshheading:21069267-Apoptosis,
pubmed-meshheading:21069267-Apoptosis Regulatory Proteins,
pubmed-meshheading:21069267-Blotting, Western,
pubmed-meshheading:21069267-Caspase 3,
pubmed-meshheading:21069267-Caspase 7,
pubmed-meshheading:21069267-Cell Death,
pubmed-meshheading:21069267-Colorectal Neoplasms,
pubmed-meshheading:21069267-Combined Modality Therapy,
pubmed-meshheading:21069267-Dose-Response Relationship, Radiation,
pubmed-meshheading:21069267-Enzyme Activation,
pubmed-meshheading:21069267-Humans,
pubmed-meshheading:21069267-Hyperthermia, Induced,
pubmed-meshheading:21069267-Necrosis,
pubmed-meshheading:21069267-Neoplastic Stem Cells,
pubmed-meshheading:21069267-Proto-Oncogene Proteins,
pubmed-meshheading:21069267-Proto-Oncogene Proteins c-bcl-6,
pubmed-meshheading:21069267-Tumor Cells, Cultured,
pubmed-meshheading:21069267-Tumor Suppressor Protein p53,
pubmed-meshheading:21069267-bcl-2-Associated X Protein
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pubmed:year |
2010
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pubmed:articleTitle |
Combination of ionising irradiation and hyperthermia activates programmed apoptotic and necrotic cell death pathways in human colorectal carcinoma cells.
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pubmed:affiliation |
Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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