Linked Life Data

21067323

Source:http://linkedlifedata.com/resource/pubmed/id/21067323

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-11-11
pubmed:abstractText
Candida species are isolated with high frequency from cystic fibrosis patients, yet their definitive role in the disease remains unclear. Previously considered to have minimal inherent virulence owing to their commensal ability, the last decade has heralded an increasing recognition of Candida infection among patients with cystic fibrosis. What has been more recently hypothesized is that the organism possesses virulence factors that play diverse roles at different body sites during varied stages of an infection. Currently, limited data is accessible in the area of cystic fibrosis. This review aims to provide an overview of the role of Candida species in cystic fibrosis as it is currently understood including the common local and systemic infections observed in clinical practice. The uncertain role of airway colonization and insight into emerging fields such as Candida-bacterial interactions are also addressed. Finally, we outline the current understanding of the innate, cellular and humoral immune responses associated with this genus which has been the major focus of work performed to date.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1460-2709
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
48 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S114-24
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Candida species in cystic fibrosis: A road less travelled.
pubmed:affiliation
Department of Medicine, Royal College of Surgeons, Ireland. schotirmall@rcsi.ie
pubmed:publicationType
Journal Article, Review