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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1990-4-6
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pubmed:abstractText |
We have investigated the effects of heat shock on T-cell induction and selection in vitro. We find that when cell preparations containing T lymphocytes are incubated for 30 min at 42 degrees C, a selective proliferation of gamma delta + T cells bearing the gamma delta T-cell antigen receptor follows. A greater enrichment of gamma delta + T cells is observed, upon preexposure to mycobacterial antigens in vivo. By comparing the effects of heat shock with that of mitogen or specific T-cell triggering by conventional antigens and by analyzing the gamma delta T-cell receptor genes expressed in cells that proliferate as a result of heat shock induction, we conclude that a subset of murine gamma delta T cells react to antigens on self cells in which a heat shock response was induced.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2427013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2439914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2471938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2473405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2524009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2524098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2524273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2526925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2528072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2528075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2528206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2544806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2546157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2653369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2726770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2784150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2788280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2847872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2943999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2961997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-2963227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-3106059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-3114383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-3132709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-3165197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-3486721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-3499575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-6166712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-6330561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-6968869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106682-92410
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1767-71
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2106682-Animals,
pubmed-meshheading:2106682-Base Sequence,
pubmed-meshheading:2106682-Cell Cycle,
pubmed-meshheading:2106682-Cells, Cultured,
pubmed-meshheading:2106682-Fluorescent Antibody Technique,
pubmed-meshheading:2106682-Hot Temperature,
pubmed-meshheading:2106682-Immunoglobulin Heavy Chains,
pubmed-meshheading:2106682-Immunoglobulin Variable Region,
pubmed-meshheading:2106682-Immunoglobulin delta-Chains,
pubmed-meshheading:2106682-Immunoglobulin lambda-Chains,
pubmed-meshheading:2106682-Lung,
pubmed-meshheading:2106682-Lymph Nodes,
pubmed-meshheading:2106682-Lymphocyte Activation,
pubmed-meshheading:2106682-Mice,
pubmed-meshheading:2106682-Mice, Inbred BALB C,
pubmed-meshheading:2106682-Molecular Sequence Data,
pubmed-meshheading:2106682-Receptors, Antigen, T-Cell,
pubmed-meshheading:2106682-T-Lymphocytes
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pubmed:year |
1990
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pubmed:articleTitle |
Self heat shock and gamma delta T-cell reactivity.
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pubmed:affiliation |
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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